General Structure Information
| PDB ID | 3ewf |
| HGNC Gene Label(s) | HDAC8 |
| Structure Name | crystal structure analysis of human hdac8 h143a variant complexed with substrate. |
| Resolution | 2.5Å |
| Reference | AUTH D.P.DOWLING,S.L.GANTT,S.G.GATTIS,C.A.FIERKE,AUTH 2 D.W.CHRISTIANSONTITL STRUCTURAL STUDIES OF HUMAN HISTONE DEACETYLASE 8TITL 2 AND ITS SITE-SPECIFIC VARIANTS COMPLEXED WITHTITL 3 SUBSTRATE AND INHIBITORS.REF BIOCHEMISTRY V. 47 13554 2008REFN ISSN 0006-2960PMID 19053282DOI 10.1021/BI801610C |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 364 |
| Number Of SNVs | 26 |
| Number Of Permutations | 9527 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.037 |
| p-value | 0.408 |
ClinVar
| Number Of Residues | 364 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1840 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.0 |
| p-value | 0.388 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 26 |
| Number Of ClinVar SNVs | 7 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.108 |
| p-value | 0.151 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
