2O2K.A | MTR – ASTRID

2O2K.A | MTR

General Structure Information

PDB ID	2o2k
HGNC Gene Label(s)	MTR
Structure Name	crystal structure of the activation domain of human methionine synthase isoform/mutant d963e/k1071n
Resolution	1.6Å
Reference	AUTH K.R.WOLTHERS,H.S.TOOGOOD,T.A.JOWITT,K.R.MARSHALL,AUTH 2 D.LEYS,N.S.SCRUTTONTITL CRYSTAL STRUCTURE AND SOLUTION CHARACTERIZATION OFTITL 2 THE ACTIVATION DOMAIN OF HUMAN METHIONINE SYNTHASEREF FEBS J. V. 274 738 2007REFN ISSN 1742-464XPMID 17288554DOI 10.1111/J.1742-4658.2006.05618.X

Variant Set Distributions

ExAC Variants

Number Of Residues	332
Number Of SNVs	74
Number Of Permutations	38708
Optimal Distance Threshold	7.0
K Statistic	0.019
p-value	0.778

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
1:237049607		P>S	A:931	(7.74, 41.75, 10.36)
1:237049623		R>K	A:936	(11.22, 43.87, 2.57)
1:237049638		Q>L	A:941	(10.17, 54.89, -0.38)
1:237049640		M>V	A:942	(14.09, 57.76, -3.61)
1:237049642		M>I	A:942	(14.09, 57.76, -3.61)
1:237052484	rs550823647	K>R	A:952	(27.56, 56.61, -17.34)
1:237052489	rs369001514	T>P	A:954	(34.04, 58.48, -16.68)
1:237052490	rs146931200	T>M	A:954	(34.04, 58.48, -16.68)
1:237052496		I>T	A:956	(32.36, 50.94, -16.75)
1:237052506		Q>H	A:959	(41.46, 53.78, -12.55)
1:237052519		Y>H	A:964	(47.68, 58.58, -5.08)
1:237052529		Q>R	A:967	(53.01, 65.75, 0.23)
1:237052533	COSM403299	K>N	A:968	(47.51, 65.52, -2.95)
1:237052544		Y>C	A:972	(42.91, 65.77, 1.48)
1:237052582	rs201015844	R>W	A:985	(51.16, 54.61, 23.70)
1:237052583	rs372611712 COSM679980	R>Q	A:985	(51.16, 54.61, 23.70)
1:237052595		P>R	A:989	(55.83, 56.83, 28.82)
1:237052601		R>Q	A:991	(64.07, 53.55, 28.14)
1:237052612	rs143338646	K>E	A:995	(62.44, 64.78, 27.29)
1:237052622		N>S	A:998	(59.37, 63.56, 31.51)
1:237052624		D>H	A:999	(57.39, 67.86, 31.30)
1:237052627		K>E	A:1000	(53.88, 69.18, 33.49)
1:237052628		K>R	A:1000	(53.88, 69.18, 33.49)
1:237054449		K>N	A:1008	(57.88, 66.92, 19.65)
1:237054450		V>F	A:1009	(53.92, 64.51, 18.35)
1:237054460	rs201901663	D>V	A:1012	(58.42, 64.51, 15.45)
1:237054469		N>S	A:1015	(60.23, 65.69, 10.49)
1:237054490		S>N	A:1022	(61.73, 61.31, 0.16)
1:237054504	rs116836001	R>W	A:1027	(55.24, 52.55, -1.88)
1:237054510	rs139771804	R>W	A:1029	(50.06, 50.05, -3.92)
1:237054511		R>Q	A:1029	(50.06, 50.05, -3.92)
1:237054519		V>I	A:1032	(38.25, 52.90, -8.72)
1:237054538		Q>R	A:1038	(19.73, 48.40, -11.26)
1:237054543		I>V	A:1040	(15.92, 43.15, -6.89)
1:237054558		H>Y	A:1045	(21.58, 42.71, -8.77)
1:237054562	rs374527196	L>Q	A:1046	(26.39, 44.99, -10.38)
1:237054567	COSM2001003	A>T	A:1048	(27.70, 44.82, -17.97)
1:237054568		A>V	A:1048	(27.70, 44.82, -17.97)
1:237054597		P>S	A:1058	(23.72, 39.50, -12.82)
1:237054602		I>M	A:1059	(28.57, 40.92, -13.05)
1:237054606	COSM370994	T>A	A:1061	(25.12, 40.60, -5.90)
1:237054609		F>L	A:1062	(27.35, 44.14, -3.69)
1:237054613		Y>C	A:1063	(23.59, 40.02, -1.44)
1:237057678		T>A	A:1076	(6.66, 56.35, 11.10)
1:237057679	rs144991102	T>M	A:1076	(6.66, 56.35, 11.10)
1:237057688		Y>S	A:1079	(11.71, 50.33, 9.02)
1:237057696		L>F	A:1082	(22.46, 50.28, 1.37)
1:237057707		F>L	A:1085	(20.29, 54.61, -0.86)
1:237057712	rs368521476	A>V	A:1087	(17.42, 52.00, -9.05)
1:237057721	rs202230081	H>R	A:1090	(11.73, 46.29, -13.22)
1:237057732	rs200363767 COSM906106	R>C	A:1094	(19.89, 52.31, -17.20)
1:237057733	COSM906107	R>H	A:1094	(19.89, 52.31, -17.20)
1:237057756		V>I	A:1102	(42.91, 52.39, -0.30)
1:237057760		A>V	A:1103	(46.75, 51.27, 0.91)
1:237057775		E>G	A:1108	(53.40, 46.18, 8.73)
1:237057789	rs146071220	A>T	A:1113	(62.71, 48.42, 12.40)
1:237057793		Y>C	A:1114	(61.46, 52.77, 13.44)
1:237057797		E>D	A:1115	(59.82, 47.77, 17.46)
1:237057828		V>I	A:1126	(54.85, 54.69, 11.40)
1:237057835		A>V	A:1128	(49.72, 56.64, 13.02)
1:237057846	rs201991154 COSM533489	R>W	A:1132	(45.30, 59.10, 9.83)
1:237058670	rs150123193	E>K	A:1140	(41.76, 62.51, -2.69)
1:237058682		R>G	A:1144	(40.31, 61.56, -8.31)
1:237058689		R>H	A:1146	(32.66, 63.52, -4.53)
1:237058694	COSM134010	E>Q	A:1148	(37.47, 64.03, -11.20)
1:237058715	rs369154176	S>G	A:1155	(30.70, 71.92, -8.83)
1:237058742		R>C	A:1164	(37.06, 66.65, 8.65)
1:237058743	rs61736326	R>H	A:1164	(37.06, 66.65, 8.65)
1:237058752	rs556429682	R>Q	A:1167	(29.01, 68.36, 3.25)
1:237058763		I>V	A:1171	(27.51, 57.16, 0.91)
1:237058766		R>C	A:1172	(33.40, 56.87, 2.00)
1:237058770	rs121913578	P>L	A:1173	(29.58, 52.38, 2.51)
1:237058835	rs149476106	I>V	A:1195	(41.30, 44.31, -5.19)
1:237060332		M>V	A:1209	(41.96, 45.24, 4.98)
1:237060372	rs61739582	N>S	A:1222	(21.34, 59.43, -4.31)
1:237060384		K>R	A:1226	(21.19, 58.60, 4.82)
1:237060387		Y>F	A:1227	(26.89, 56.83, 6.05)
1:237060395	rs138451899	V>L	A:1230	(20.84, 47.72, 10.40)
1:237060411		K>R	A:1235	(15.27, 34.41, 12.25)
1:237060883	rs150280831	N>S	A:1246	(23.60, 29.70, -1.45)
1:237060885		I>V	A:1247	(24.85, 31.11, 2.99)
1:237060888		S>P	A:1248	(24.14, 28.72, 6.29)
1:237060916	rs374409316 COSM384202	G>V	A:1257	(25.92, 38.30, 15.70)