General Structure Information
| PDB ID | 4clt |
| HGNC Gene Label(s) | ADCY10 |
| Structure Name | crystal structure of human soluble adenylyl cyclase with adenosine-3,5-cyclic-monophosphate and pyrophosphate |
| Resolution | 1.95Å |
| Reference | AUTH S.KLEINBOELTING,A.DIAZ,S.MONIOT,J.VAN DEN HEUVEL,M.WEYAND,AUTH 2 L.R.LEVIN,J.BUCK,C.STEEGBORNTITL CRYSTAL STRUCTURES OF HUMAN SOLUBLE ADENYLYL CYCLASE REVEALTITL 2 MECHANISMS OF CATALYSIS AND OF ITS ACTIVATION THROUGHTITL 3 BICARBONATE.REF PROC.NATL.ACAD.SCI.USA V. 111 3727 2014REFN ISSN 0027-8424PMID 24567411DOI 10.1073/PNAS.132277811 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 461 |
| Number Of SNVs | 122 |
| Number Of Permutations | 34971 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.072 |
| p-value | 0.63 |
COSMIC
| Number Of Residues | 461 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.333 |
| p-value | 0.302 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 122 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.278 |
| p-value | 0.133 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
