4JT6.D | MLST8

General Structure Information

PDB ID	4jt6
HGNC Gene Label(s)	MLST8
Structure Name	structure of mtordeltan-mlst8-pi-103 complex
Resolution	3.6Å
Reference	AUTH H.YANG,D.G.RUDGE,J.D.KOOS,B.VAIDIALINGAM,H.J.YANG,AUTH 2 N.P.PAVLETICHTITL MTOR KINASE STRUCTURE, MECHANISM AND REGULATION.REF NATURE V. 497 217 2013REFN ISSN 0028-0836PMID 23636326DOI 10.1038/NATURE12122

Variant Set Distributions

ExAC Variants

Number Of Residues	317
Number Of SNVs	75
Number Of Permutations	9340
Optimal Distance Threshold	16.0
K Statistic	0.214
p-value	0.788

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
16:2256138		A>S	D:18	(-13.96, 6.56, -80.00)
16:2256141		G>R	D:19	(-15.38, 3.29, -78.62)
16:2256156		V>M	D:24	(-16.21, 6.87, -85.19)
16:2256179	rs371717510	S>R	D:31	(-20.68, 23.57, -81.27)
16:2256180		G>S	D:32	(-20.99, 20.25, -80.25)
16:2256359		Q>E	D:44	(-12.53, -2.09, -78.99)
16:2256377		V>I	D:50	(-5.61, 12.24, -88.57)
16:2256378		V>A	D:50	(-5.61, 12.24, -88.57)
16:2256384	rs374766503	P>L	D:52	(-0.40, 13.67, -92.11)
16:2256389		R>C	D:54	(-6.69, 17.29, -92.93)
16:2256401		A>T	D:58	(-7.16, 5.76, -88.00)
16:2256405		A>V	D:59	(-9.02, 2.68, -86.47)
16:2256500		Y>H	D:62	(-9.18, -7.86, -81.32)
16:2256501		Y>F	D:62	(-9.18, -7.86, -81.32)
16:2256513	rs373967086	R>P	D:66	(-11.89, -1.11, -89.12)
16:2256515		M>L	D:67	(-8.21, 3.74, -92.54)
16:2256537		N>S	D:74	(-20.73, 9.38, -96.68)
16:2256546		P>L	D:77	(-13.93, 1.01, -94.54)
16:2256548		I>V	D:78	(-10.61, 3.33, -97.52)
16:2256566		V>L	D:84	(-2.69, -9.13, -86.78)
16:2256593		F>L	D:93	(0.17, 7.90, -89.78)
16:2256654		D>G	D:113	(3.07, 0.51, -97.96)
16:2257040		R>W	D:117	(-3.10, -4.17, -103.78)
16:2257041		R>Q	D:117	(-3.10, -4.17, -103.78)
16:2257046		L>M	D:119	(-3.45, -7.59, -95.25)
16:2257059		R>Q	D:123	(10.58, -2.60, -91.82)
16:2257070	rs374173728	V>M	D:127	(9.67, -7.36, -78.42)
16:2257087		N>K	D:132	(1.40, -0.53, -74.78)
16:2257095		C>Y	D:135	(6.45, 7.34, -81.33)
16:2257195		A>V	D:141	(14.50, 7.96, -88.48)
16:2257260		E>K	D:163	(19.78, 0.85, -78.91)
16:2257282		E>A	D:170	(9.83, -4.73, -64.17)
16:2257294	rs201789867	T>M	D:174	(1.46, 3.40, -70.94)
16:2257299	rs200523182	A>T	D:176	(5.26, 7.88, -75.50)
16:2257304		H>Q	D:177	(5.02, 12.56, -77.30)
16:2257314	COSM3711977 COSM3711976 COSM3711975	D>N	D:181	(11.49, 21.31, -81.24)
16:2257339		N>S	D:189	(4.66, 4.30, -65.76)
16:2257345		T>N	D:191	(3.44, 3.54, -61.24)
16:2258220		Y>H	D:195	(10.37, 8.48, -66.09)
16:2258233		L>P	D:199	(16.73, 14.59, -77.29)
16:2258238		G>R	D:201	(21.23, 15.69, -82.01)
16:2258245	rs368540170	I>T	D:203	(20.10, 13.63, -86.57)
16:2258247		G>S	D:204	(22.51, 12.87, -89.91)
16:2258248		G>D	D:204	(22.51, 12.87, -89.91)
16:2258253		E>Q	D:206	(21.48, 8.96, -87.19)
16:2258255		E>D	D:206	(21.48, 8.96, -87.19)
16:2258263		Q>R	D:209	(21.65, 9.15, -77.46)
16:2258287		P>L	D:217	(5.42, 12.35, -59.29)
16:2258299		R>H	D:221	(-5.62, 5.30, -60.24)
16:2258305		A>V	D:223	(-0.70, 6.46, -66.44)
16:2258311	rs534962837	Q>R	D:225	(-1.71, 9.75, -73.03)
16:2258316	rs375231338	R>C	D:227	(0.04, 14.28, -76.92)
16:2258462		T>S	D:237	(-0.49, 13.51, -67.84)
16:2258480		T>M	D:243	(-6.64, 13.56, -64.12)
16:2258498		T>M	D:249	(8.90, 22.11, -70.13)
16:2258510		S>F	D:253	(5.57, 22.64, -62.83)
16:2258519		T>M	D:256	(-3.58, 23.06, -65.42)
16:2258521		E>Q	D:257	(-5.78, 19.33, -62.11)
16:2258522		E>V	D:257	(-5.78, 19.33, -62.11)
16:2258534		K>R	D:261	(-12.13, 14.24, -59.14)
16:2258537		S>I	D:262	(-17.29, 13.44, -58.30)
16:2258539	rs567308797	G>S	D:263	(-18.02, 15.55, -54.96)
16:2258548		G>R	D:266	(-19.28, 8.27, -52.70)
16:2258555		S>C	D:268	(-17.30, 5.05, -57.62)
16:2258561		R>H	D:270	(-18.67, 6.95, -64.58)
16:2258575	rs201091044	G>S	D:275	(-7.10, 11.12, -73.76)
16:2258579	rs368651599	C>Y	D:276	(-4.94, 14.04, -74.97)
16:2258581		A>T	D:277	(-5.39, 16.75, -77.85)
16:2258588		S>L	D:279	(-4.37, 23.07, -79.89)
16:2258608	rs374883203	V>I	D:286	(-9.16, 17.60, -76.31)
16:2258614		A>T	D:288	(-11.06, 11.23, -73.32)
16:2258763		S>C	D:289	(-13.79, 10.14, -71.08)
16:2258766		S>L	D:290	(-15.27, 6.50, -69.67)
16:2258772		N>T	D:292	(-19.82, 8.37, -72.46)
16:2258777		A>T	D:294	(-15.60, 14.79, -74.91)
16:2258780		R>W	D:295	(-14.87, 16.71, -71.27)
16:2258781		R>Q	D:295	(-14.87, 16.71, -71.27)
16:2258790		C>Y	D:298	(-8.60, 26.38, -71.10)
16:2258802		G>A	D:302	(-9.48, 24.96, -66.80)
16:2258818		E>D	D:307	(-19.78, 18.52, -72.48)
16:2258825		G>S	D:310	(-23.15, 10.84, -77.70)
16:2258826		G>D	D:310	(-23.15, 10.84, -77.70)
16:2258867		V>M	D:324	(-2.94, 24.98, -93.69)