General Structure Information
| PDB ID | 3qf2 |
| HGNC Gene Label(s) | NLRP3 |
| Structure Name | crystal structure of nalp3 pyd |
| Resolution | 1.7Å |
| Reference | AUTH J.Y.BAE,H.H.PARKTITL CRYSTAL STRUCTURE OF NALP3 PROTEIN PYRIN DOMAIN (PYD) ANDTITL 2 ITS IMPLICATIONS IN INFLAMMASOME ASSEMBLYREF J.BIOL.CHEM. V. 286 39528 2011REFN ISSN 0021-9258PMID 21880711DOI 10.1074/JBC.M111.278812 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 106 |
| Number Of SNVs | 27 |
| Number Of Permutations | 1858 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.094 |
| p-value | 0.663 |
COSMIC
| Number Of Residues | 106 |
| Number Of SNVs | 4 |
| Number Of Permutations | 96 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.167 |
| p-value | 0.944 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 27 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | -0.073 |
| p-value | 0.714 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
