General Structure Information
| PDB ID | 2nsq |
| HGNC Gene Label(s) | NEDD4L |
| Structure Name | crystal structure of the c2 domain of the human e3 ubiquitin-protein ligase nedd4-like protein |
| Resolution | 1.85Å |
| Reference | AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL THE C2 DOMAIN OF THE HUMAN E3 UBIQUITIN-PROTEIN LIGASETITL 2 NEDD4-LIKE PROTEINREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 140 |
| Number Of SNVs | 21 |
| Number Of Permutations | 1892 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.071 |
| p-value | 0.574 |
COSMIC
| Number Of Residues | 140 |
| Number Of SNVs | 3 |
| Number Of Permutations | 109 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.333 |
| p-value | 0.971 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 21 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.21 |
| p-value | 0.603 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
