General Structure Information
| PDB ID | 2d4c |
| HGNC Gene Label(s) | SH3GL2 |
| Structure Name | crystal structure of the endophilin bar domain mutant |
| Resolution | 2.4Å |
| Reference | AUTH M.MASUDA,S.TAKEDA,M.SONE,T.OHKI,H.MORI,Y.KAMIOKA,AUTH 2 N.MOCHIZUKITITL ENDOPHILIN BAR DOMAIN DRIVES MEMBRANE CURVATURE BYTITL 2 TWO NEWLY IDENTIFIED STRUCTURE-BASED MECHANISMSREF EMBO J. V. 25 2889 2006REFN ISSN 0261-4189PMID 16763557DOI 10.1038/SJ.EMBOJ.7601176 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 226 |
| Number Of SNVs | 39 |
| Number Of Permutations | 39679 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.109 |
| p-value | 0.344 |
COSMIC
| Number Of Residues | 226 |
| Number Of SNVs | 6 |
| Number Of Permutations | 6738 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.2 |
| p-value | 0.4 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 39 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.233 |
| p-value | 0.211 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
