4LDQ.A | MRI1 – ASTRID

4LDQ.A | MRI1

General Structure Information

PDB ID	4ldq
HGNC Gene Label(s)	MRI1
Structure Name	crystal structure of the mediator of rho dependent invasion
Resolution	2.5Å
Reference	AUTH P.D.TEMPLETON,E.S.LITMAN,S.I.METZNER,N.G.AHN,M.C.SOUSATITL STRUCTURE OF MEDIATOR OF RHOA-DEPENDENT INVASION (MRDI)TITL 2 EXPLAINS ITS DUAL FUNCTION AS A METABOLIC ENZYME AND ATITL 3 MEDIATOR OF CELL INVASION.REF BIOCHEMISTRY V. 52 5675 2013REFN ISSN 0006-2960PMID 23859498DOI 10.1021/BI400556E

Variant Set Distributions

ExAC Variants

Number Of Residues	353
Number Of SNVs	94
Number Of Permutations	54682
Optimal Distance Threshold	10.0
K Statistic	0.059
p-value	0.397

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
19:13875406		T>A	A:2	(37.49, 45.78, 20.06)
19:13875412		E>Q	A:4	(38.62, 41.58, 16.35)
19:13875421	rs79169978	R>C	A:7	(41.78, 39.32, 13.29)
19:13875430		R>W	A:10	(38.52, 45.14, -0.50)
19:13875433		G>S	A:11	(41.27, 40.30, 0.41)
19:13875434	rs372185077	G>D	A:11	(41.27, 40.30, 0.41)
19:13875437	rs137877795	S>F	A:12	(42.15, 39.42, 4.22)
19:13875478		R>S	A:26	(44.11, 27.86, 16.52)
19:13875479		R>H	A:26	(44.11, 27.86, 16.52)
19:13875497		S>L	A:32	(37.00, 29.78, 0.37)
19:13875706		A>S	A:52	(25.81, 36.19, 8.20)
19:13875712		V>M	A:54	(32.13, 34.66, 8.41)
19:13875746	COSM1215470 COSM1215471	A>V	A:65	(39.83, 36.33, -6.20)
19:13875764		G>E	A:71	(30.76, 38.38, -18.05)
19:13875821	rs201171443	R>L	A:90	(24.68, 26.91, 12.39)
19:13875842	rs191268733	A>G	A:97	(18.82, 33.57, 4.87)
19:13875862	rs375919540	A>S	A:104	(20.95, 38.31, -4.16)
19:13875902		T>M	A:117	(30.43, 46.36, -15.93)
19:13875904	rs200063247	E>K	A:118	(31.84, 41.51, -14.99)
19:13875923	rs368380667	R>T	A:124	(27.33, 47.81, -5.00)
19:13876776		C>F	A:127	(31.61, 47.70, -1.44)
19:13876779		C>Y	A:128	(27.47, 45.74, -0.11)
19:13876784	rs368436044	E>K	A:130	(33.14, 45.85, 2.80)
19:13876785	rs139570296	E>G	A:130	(33.14, 45.85, 2.80)
19:13876790		M>L	A:132	(26.47, 43.85, 5.21)
19:13876809		R>K	A:138	(27.39, 52.15, 11.64)
19:13876813	rs543064596	D>E	A:139	(24.56, 49.48, 14.61)
19:13876818	rs533532100	R>Q	A:141	(31.07, 51.00, 18.41)
19:13876823		I>V	A:143	(23.08, 48.84, 20.83)
19:13876824		I>T	A:143	(23.08, 48.84, 20.83)
19:13876836	rs149309863	G>E	A:147	(22.69, 52.54, 26.46)
19:13876841	rs551664067	R>C	A:149	(23.71, 59.79, 28.17)
19:13876842		R>H	A:149	(23.71, 59.79, 28.17)
19:13876844		H>Y	A:150	(18.89, 55.62, 29.37)
19:13876857		R>Q	A:154	(16.66, 55.08, 34.66)
19:13876859		V>L	A:155	(21.54, 53.93, 37.81)
19:13876863	rs140094235	A>V	A:156	(24.37, 57.40, 38.38)
19:13876865		P>S	A:157	(21.80, 60.80, 38.29)
19:13876884		T>I	A:163	(27.83, 47.21, 39.47)
19:13876892		T>A	A:166	(25.65, 40.36, 31.81)
19:13876905		T>S	A:170	(25.64, 39.53, 24.41)
19:13876913		L>V	A:173	(33.15, 35.74, 21.45)
19:13876916	COSM4131258	A>T	A:174	(27.77, 36.86, 19.90)
19:13876922	rs139240039	A>T	A:176	(30.31, 41.52, 14.16)
19:13876929		Y>C	A:178	(31.64, 47.37, 21.24)
19:13876938		A>G	A:181	(24.51, 43.67, 26.40)
19:13879382		I>M	A:185	(29.32, 45.91, 30.23)
19:13879383	rs371177220	R>C	A:186	(33.11, 45.90, 25.19)
19:13879386		S>P	A:187	(30.33, 51.84, 26.42)
19:13879393	rs199781657	H>R	A:189	(35.73, 50.05, 31.00)
19:13879395	rs201849282	S>G	A:190	(35.26, 53.57, 27.60)
19:13879404	rs373257975	R>C	A:193	(30.33, 56.98, 34.82)
19:13879405	rs142977800	R>H	A:193	(30.33, 56.98, 34.82)
19:13879419	rs377336322	F>L	A:198	(28.94, 40.96, 39.07)
19:13879434	rs373288448	R>W	A:203	(24.44, 24.96, 33.31)
19:13879435		R>Q	A:203	(24.44, 24.96, 33.31)
19:13879437		P>S	A:204	(22.60, 24.27, 29.89)
19:13879446		Q>E	A:207	(27.01, 30.62, 26.26)
19:13879449	rs151129587	G>R	A:208	(29.10, 33.14, 30.28)
19:13879456	rs141094096	R>Q	A:210	(32.88, 28.52, 26.64)
19:13879462		T>M	A:212	(30.97, 36.86, 29.00)
19:13879477	rs377309624	V>G	A:217	(39.75, 38.39, 31.28)
19:13879480	rs202028355	Y>C	A:218	(40.93, 40.35, 24.96)
19:13879489		I>N	A:221	(36.01, 45.10, 31.38)
19:13879494		A>T	A:223	(34.89, 41.19, 35.96)
19:13879530	rs35098252	M>V	A:235	(20.85, 41.69, 42.31)
19:13879531		M>T	A:235	(20.85, 41.69, 42.31)
19:13879536		H>Y	A:237	(24.28, 40.91, 49.77)
19:13879545		V>M	A:240	(24.05, 44.67, 40.86)
19:13879551	rs201287083	A>T	A:242	(22.03, 47.72, 36.42)
19:13879643		V>I	A:244	(22.34, 45.28, 30.37)
19:13879659		R>H	A:249	(12.06, 36.44, 17.99)
19:13879664		V>I	A:251	(7.50, 40.29, 20.46)
19:13879671	COSM1286268 COSM1286269	N>S	A:253	(4.23, 43.82, 23.50)
19:13879673	rs370685063	G>S	A:254	(8.37, 44.18, 24.00)
19:13879680	rs141252695	T>R	A:256	(12.30, 39.88, 25.37)
19:13879682	rs202149144	A>T	A:257	(12.52, 35.94, 23.71)
19:13879691		V>M	A:260	(16.77, 29.70, 29.89)
19:13879692		V>A	A:260	(16.77, 29.70, 29.89)
19:13879718		A>T	A:269	(15.94, 42.92, 38.94)
19:13879725	rs201448827	H>P	A:271	(13.01, 41.68, 45.34)
19:13879730	rs146948667	G>R	A:273	(14.75, 47.77, 42.48)
19:13879743	rs191513721	Y>C	A:277	(18.38, 48.72, 30.82)
19:13879763		S>P	A:284	(16.60, 41.37, 16.88)
19:13879766	rs76748804	C>R	A:285	(13.05, 43.82, 16.91)
19:13879776	rs201162998	R>H	A:288	(6.70, 38.84, 11.52)
19:13879781	rs143734805	E>K	A:290	(1.17, 41.62, 18.72)
19:13879797		I>N	A:295	(7.66, 33.89, 21.65)
19:13879817		G>S	A:302	(18.48, 16.46, 28.01)
19:13879827	rs373564107	L>Q	A:305	(20.53, 19.83, 31.78)
19:13879832	rs143025796	D>N	A:307	(26.29, 15.64, 30.21)
19:13879835		V>I	A:308	(29.38, 18.95, 32.39)
19:13879841	rs373564044	G>W	A:310	(31.20, 14.39, 28.33)
19:13879845		V>A	A:311	(31.43, 13.50, 32.43)
19:13879847		R>W	A:312	(24.41, 11.55, 33.24)
19:13879848	rs201584786	R>Q	A:312	(24.41, 11.55, 33.24)
19:13879862		G>R	A:317	(17.14, 8.38, 35.10)
19:13882938		I>T	A:318	(16.32, 12.77, 36.78)
19:13882963		D>E	A:326	(12.72, 32.37, 29.24)
19:13882976	rs142055515	D>N	A:331	(5.53, 44.87, 32.89)
19:13882979	rs146318982	L>F	A:332	(9.39, 42.26, 34.70)
19:13883012	rs201521540	V>I	A:343	(16.89, 53.52, 25.56)
19:13883019		A>V	A:345	(9.60, 52.54, 26.52)
19:13883033	rs576589138	R>W	A:350	(3.76, 47.97, 16.83)
19:13883034	rs139306023	R>Q	A:350	(3.76, 47.97, 16.83)