General Structure Information
| PDB ID | 1nd7 |
| HGNC Gene Label(s) | WWP1 |
| Structure Name | conformational flexibility underlies ubiquitin ligation mediated by the wwp1 hect domain e3 ligase |
| Resolution | 2.1Å |
| Reference | AUTH M.A.VERDECIA,C.A.P.JOAZIERO,N.J.WELLS,J.-L.FERRER,AUTH 2 M.E.BOWMAN,T.HUNTER,J.P.NOELTITL CONFORMATIONAL FLEXIBILITY UNDERLIES UBIQUITINTITL 2 LIGATION MEDIATED BY THE WWP1 HECT DOMAIN E3 LIGASEREF MOL.CELL V. 11 249 2003REFN ISSN 1097-2765PMID 12535537DOI 10.1016/S1097-2765(02)00774-8 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 372 |
| Number Of SNVs | 54 |
| Number Of Permutations | 11692 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.021 |
| p-value | 0.59 |
COSMIC
| Number Of Residues | 372 |
| Number Of SNVs | 3 |
| Number Of Permutations | 345 |
| Optimal Distance Threshold | 46.0 |
| K Statistic | 0.667 |
| p-value | 0.801 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 54 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | -0.407 |
| p-value | 0.45 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
