General Structure Information
| PDB ID | 2wmn |
| HGNC Gene Label(s) | DOCK9 |
| Structure Name | structure of the complex between dock9 and cdc42-gdp. |
| Resolution | 2.39Å |
| Reference | AUTH J.YANG,Z.ZHANG,S.M.ROE,C.J.MARSHALL,D.BARFORDTITL ACTIVATION OF RHO GTPASES BY DOCK EXCHANGE FACTORSTITL 2 IS MEDIATED BY A NUCLEOTIDE SENSOR.REF SCIENCE V. 325 1398 2009REFN ISSN 0036-8075PMID 19745154DOI 10.1126/SCIENCE.1174468 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 402 |
| Number Of SNVs | 86 |
| Number Of Permutations | 50277 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.043 |
| p-value | 0.366 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 13:99481614 | T>A | A:12 | (-57.58, 15.14, -33.09) | |
| 13:99481605 | D>N | A:15 | (-55.14, 18.26, -29.51) | |
| 13:99481592 | R>K | A:19 | (-54.67, 15.42, -24.57) | |
| 13:99479120 | rs376491903 | V>I | A:37 | (-53.17, 23.24, -34.04) |
| 13:99479113 | A>V | A:39 | (-50.96, 26.89, -37.98) | |
| 13:99479108 | V>M | A:41 | (-56.59, 27.15, -37.86) | |
| 13:99479090 | rs371892069 COSM258742 |
R>W | A:47 | (-56.08, 29.11, -48.22) |
| 13:99476756 | V>M | A:50 | (-60.87, 35.35, -41.75) | |
| 13:99476735 | A>T | A:57 | (-45.66, 33.43, -38.62) | |
| 13:99476728 | rs535191163 | R>M | A:59 | (-40.58, 28.62, -41.01) |
| 13:99476729 | R>G | A:59 | (-40.58, 28.62, -41.01) | |
| 13:99476726 | V>I | A:60 | (-40.31, 32.00, -36.35) | |
| 13:99476699 | rs370702552 | A>T | A:69 | (-49.27, 21.20, -46.23) |
| 13:99462542 | V>L | A:86 | (-61.14, 29.06, -32.54) | |
| 13:99462510 | rs61745974 | D>E | A:96 | (-50.29, 30.02, -21.78) |
| 13:99462496 | A>D | A:101 | (-41.74, 25.58, -21.69) | |
| 13:99462491 | R>C | A:103 | (-38.82, 27.20, -25.24) | |
| 13:99462488 | Y>H | A:104 | (-39.90, 32.37, -20.99) | |
| 13:99462472 | D>V | A:109 | (-43.66, 35.40, -32.32) | |
| 13:99462473 | rs61745987 | D>N | A:109 | (-43.66, 35.40, -32.32) |
| 13:99462460 | L>R | A:113 | (-50.58, 36.86, -34.60) | |
| 13:99462457 | rs374501385 | I>T | A:114 | (-54.17, 38.16, -30.77) |
| 13:99462437 | R>W | A:121 | (-62.77, 41.87, -30.86) | |
| 13:99461713 | A>T | A:128 | (-53.38, 43.81, -20.28) | |
| 13:99461700 | D>G | A:132 | (-48.58, 41.00, -17.51) | |
| 13:99461697 | rs546418845 | T>M | A:133 | (-47.39, 37.66, -20.16) |
| 13:99461688 | R>Q | A:136 | (-44.81, 38.61, -15.50) | |
| 13:99461686 | A>S | A:137 | (-41.24, 36.97, -20.06) | |
| 13:99461660 | M>I | A:145 | (-29.71, 35.23, -19.72) | |
| 13:99461655 | COSM3470162 COSM3470163 COSM3470164 COSM3470161 |
S>L | A:147 | (-29.62, 32.03, -13.14) |
| 13:99461650 | rs371100286 COSM551951 COSM1649059 COSM1140441 |
R>C | A:149 | (-31.44, 28.72, -11.69) |
| 13:99461643 | L>H | A:151 | (-32.76, 23.35, -17.30) | |
| 13:99461623 | V>I | A:158 | (-31.09, 6.09, -29.37) | |
| 13:99461611 | G>R | A:162 | (-33.12, -6.62, -33.34) | |
| 13:99460053 | F>L | A:166 | (-36.40, -3.66, -31.24) | |
| 13:99460042 | D>G | A:170 | (-33.29, -3.20, -36.72) | |
| 13:99460030 | rs369791591 | Y>F | A:174 | (-34.95, 7.23, -33.31) |
| 13:99460022 | K>E | A:177 | (-35.83, 16.39, -25.77) | |
| 13:99460016 | P>S | A:179 | (-35.73, 15.69, -19.16) | |
| 13:99459997 | rs532217839 COSM4048952 COSM4048953 COSM4048951 |
S>L | A:185 | (-26.95, 7.27, -16.23) |
| 13:99459984 | COSM551952 COSM1649060 COSM1140440 |
Q>H | A:189 | (-30.68, 2.64, -16.25) |
| 13:99459985 | rs372996206 | Q>R | A:189 | (-30.68, 2.64, -16.25) |
| 13:99459977 | L>F | A:192 | (-33.06, -1.69, -19.29) | |
| 13:99459970 | rs369562954 | L>Q | A:194 | (-39.11, 0.29, -21.41) |
| 13:99459943 | N>S | A:203 | (-34.02, -10.85, -23.25) | |
| 13:99459937 | rs375165363 | K>R | A:205 | (-28.48, -5.59, -24.46) |
| 13:99459931 | rs3211042 | I>K | A:207 | (-24.31, -1.12, -27.10) |
| 13:99459926 | D>N | A:209 | (-19.15, 1.76, -28.06) | |
| 13:99457459 | N>I | A:214 | (-21.25, -4.33, -37.33) | |
| 13:99457417 | T>I | A:228 | (-24.68, 8.45, -27.51) | |
| 13:99457409 | rs368317019 | I>F | A:231 | (-23.86, 18.54, -28.05) |
| 13:99457372 | K>R | A:243 | (-26.01, 35.92, -31.12) | |
| 13:99457342 | rs369712024 | R>H | A:253 | (-32.34, 19.60, -38.62) |
| 13:99457340 | R>C | A:254 | (-26.33, 20.28, -37.39) | |
| 13:99457292 | G>R | A:270 | (-1.44, 8.54, -26.14) | |
| 13:99457286 | rs200031473 | E>K | A:272 | (1.61, 9.89, -28.77) |
| 13:99457283 | E>K | A:273 | (-1.22, 7.31, -30.09) | |
| 13:99457271 | R>W | A:277 | (-14.16, 9.52, -35.72) | |
| 13:99457267 | R>H | A:278 | (-15.84, 16.52, -34.48) | |
| 13:99457268 | rs373489385 COSM166533 |
R>C | A:278 | (-15.84, 16.52, -34.48) |
| 13:99452726 | H>R | A:285 | (-38.38, 16.86, -38.32) | |
| 13:99452719 | F>L | A:287 | (-35.41, 18.58, -31.38) | |
| 13:99452711 | rs375392160 | V>A | A:290 | (-44.84, 17.06, -32.03) |
| 13:99452690 | M>T | A:297 | (-31.75, 12.85, -42.29) | |
| 13:99452685 | Q>K | A:299 | (-24.54, 10.14, -39.88) | |
| 13:99452680 | rs576995379 | H>Q | A:300 | (-20.90, 14.27, -41.15) |
| 13:99452661 | I>F | A:307 | (-1.32, 18.18, -33.00) | |
| 13:99452629 | K>N | A:317 | (-8.69, 24.68, -20.18) | |
| 13:99452624 | rs543609412 COSM1195790 COSM1195789 |
A>V | A:319 | (-11.33, 30.01, -22.58) |
| 13:99452615 | rs201927938 | R>Q | A:322 | (-8.80, 33.97, -21.40) |
| 13:99452616 | rs377181227 | R>W | A:322 | (-8.80, 33.97, -21.40) |
| 13:99452612 | Q>R | A:323 | (-15.64, 32.73, -18.52) | |
| 13:99452600 | rs368761374 | S>L | A:327 | (-16.04, 37.71, -14.47) |
| 13:99449739 | COSM3987487 COSM3987488 COSM3987486 |
N>S | A:348 | (-4.16, 13.18, -15.29) |
| 13:99449737 | A>P | A:349 | (-0.40, 14.06, -17.31) | |
| 13:99449718 | A>V | A:355 | (5.15, 19.98, -25.24) | |
| 13:99449715 | R>Q | A:356 | (6.97, 17.07, -22.20) | |
| 13:99449713 | A>T | A:357 | (5.38, 15.30, -27.80) | |
| 13:99449703 | D>G | A:360 | (11.24, 19.08, -29.23) | |
| 13:99449488 | G>S | A:387 | (-1.85, 34.08, -13.98) | |
| 13:99449482 | A>T | A:389 | (-5.67, 33.03, -12.18) | |
| 13:99449475 | A>V | A:391 | (-4.10, 36.94, -9.71) | |
| 13:99449463 | R>H | A:395 | (-8.02, 38.16, -4.14) | |
| 13:99449464 | R>C | A:395 | (-8.02, 38.16, -4.14) | |
| 13:99449418 | rs377105888 | A>V | A:410 | (4.98, 27.28, -7.69) |
| 13:99449415 | N>S | A:411 | (3.36, 24.32, -9.58) | |
| 13:99449412 | Y>C | A:412 | (2.57, 29.92, -13.51) | |
| 13:99449410 | R>G | A:413 | (6.27, 30.46, -10.25) | |
| 13:99449400 | COSM949177 COSM1152675 |
A>V | A:416 | (6.94, 28.18, -16.97) |
| 13:99449401 | A>T | A:416 | (6.94, 28.18, -16.97) | |
| 13:99449386 | E>Q | A:421 | (13.18, 24.34, -21.23) | |
| 13:99449373 | COSM3772864 COSM3772865 COSM3772863 |
E>G | A:425 | (9.78, 31.52, -25.88) |
| 13:99449370 | rs373831225 | Q>R | A:426 | (9.39, 33.54, -22.24) |