General Structure Information
| PDB ID | 3b13 |
| HGNC Gene Label(s) | DOCK2 |
| Structure Name | crystal structure of the dhr-2 domain of dock2 in complex with rac1 (t17n mutant) |
| Resolution | 3.01Å |
| Reference | AUTH K.HANAWA-SUETSUGU,M.KUKIMOTO-NIINO,C.MISHIMA-TSUMAGARI,AUTH 2 R.AKASAKA,N.OHSAWA,S.SEKINE,T.ITO,N.TOCHIO,S.KOSHIBA,AUTH 3 T.KIGAWA,T.TERADA,M.SHIROUZU,A.NISHIKIMI,T.URUNO,T.KATAKAI,AUTH 4 T.KINASHI,D.KOHDA,Y.FUKUI,S.YOKOYAMATITL STRUCTURAL BASIS FOR MUTUAL RELIEF OF THE RAC GUANINETITL 2 NUCLEOTIDE EXCHANGE FACTOR DOCK2 AND ITS PARTNER ELMO1 FROMTITL 3 THEIR AUTOINHIBITED FORMS.REF PROC.NATL.ACAD.SCI.USA V. 109 3305 2012REFN ISSN 0027-8424PMID 22331897DOI 10.1073/PNAS.1113512109 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 427 |
| Number Of SNVs | 93 |
| Number Of Permutations | 54709 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.022 |
| p-value | 0.27 |
COSMIC
| Number Of Residues | 427 |
| Number Of SNVs | 21 |
| Number Of Permutations | 7531 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.043 |
| p-value | 0.271 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 93 |
| Number Of COSMIC SNVs | 19 |
| Optimal Distance Threshold | 39.0 |
| K Statistic | -0.145 |
| p-value | 0.265 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
