General Structure Information
| PDB ID | 3tht |
| HGNC Gene Label(s) | ALKBH8 |
| Structure Name | crystal structure and rna binding properties of the rrm/alkb domains in human abh8, an enzyme catalyzing trna hypermodification, northeast structural genomics consortium target hr5601b |
| Resolution | 3.01Å |
| Reference | AUTH C.PASTORE,I.TOPALIDOU,F.FOROUHAR,A.C.YAN,M.LEVY,J.F.HUNTTITL CRYSTAL STRUCTURE AND RNA BINDING PROPERTIES OF THE RNATITL 2 RECOGNITION MOTIF (RRM) AND ALKB DOMAINS IN HUMAN ALKBTITL 3 HOMOLOG 8 (ABH8), AN ENZYME CATALYZING TRNATITL 4 HYPERMODIFICATION.REF J.BIOL.CHEM. V. 287 2130 2012REFN ISSN 0021-9258PMID 22065580DOI 10.1074/JBC.M111.286187 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 294 |
| Number Of SNVs | 66 |
| Number Of Permutations | 11967 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.389 |
| p-value | 0.014 |
COSMIC
| Number Of Residues | 294 |
| Number Of SNVs | 4 |
| Number Of Permutations | 16 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.167 |
| p-value | 0.945 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 66 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | -0.363 |
| p-value | 0.359 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
