General Structure Information
| PDB ID | 3kvw |
| HGNC Gene Label(s) | DYRK2 |
| Structure Name | crystal structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (dyrk2) in complex with an indirubin ligand |
| Resolution | 2.28Å |
| Reference | AUTH P.FILIPPAKOPOULOS,V.MYRIANTHOPOULOS,M.KRITSANIDA,P.MAGIATIS,AUTH 2 A.L.SKALTSOUNIS,M.SOUNDARARAJAN,T.KROJER,O.GILEADI,E.HAPKA,AUTH 3 O.FEDOROV,G.BERRIDGE,J.WANG,L.SHRESTHA,M.VOLLMAR,AUTH 4 F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 5 E.MIKROS,S.KNAPPTITL CRYSTAL STRUCTURE OF DUAL-SPECIFICITY TYROSINETITL 2 PHOSPHORYLATION REGULATED KINASE 2 (DYRK2) IN COMPLEX WITHTITL 3 AN INDIRUBIN LIGANDREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 387 |
| Number Of SNVs | 90 |
| Number Of Permutations | 37896 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | 0.448 |
| p-value | 0.022 |
COSMIC
| Number Of Residues | 387 |
| Number Of SNVs | 3 |
| Number Of Permutations | 141 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.333 |
| p-value | 0.697 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 90 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.234 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
