General Structure Information
| PDB ID | 3a98 |
| HGNC Gene Label(s) | ELMO1 |
| Structure Name | crystal structure of the complex of the interacting regions of dock2 and elmo1 |
| Resolution | 2.1Å |
| Reference | AUTH K.HANAWA-SUETSUGU,M.KUKIMOTO-NIINO,C.MISHIMA-TSUMAGARI,AUTH 2 R.AKASAKA,N.OHSAWA,S.SEKINE,T.ITO,N.TOCHIO,S.KOSHIBA,AUTH 3 T.KIGAWA,T.TERADA,M.SHIROUZU,D.KOHDA,A.NISHIKIMI,Y.FUKUI,AUTH 4 S.YOKOYAMATITL STRUCTURAL BASIS OF FUNCTIONAL COMPLEX FORMATION BETWEENTITL 2 DOCK2 AND ELMO1 FOR RAC ACTIVATION IN LYMPHOCYTE CHEMOTAXISREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 160 |
| Number Of SNVs | 23 |
| Number Of Permutations | 7612 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.186 |
| p-value | 0.078 |
COSMIC
| Number Of Residues | 160 |
| Number Of SNVs | 5 |
| Number Of Permutations | 616 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.9 |
| p-value | 0.134 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 23 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.553 |
| p-value | 0.577 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
