General Structure Information
| PDB ID | 3ngo |
| HGNC Gene Label(s) | CNOT6L |
| Structure Name | crystal structure of the human cnot6l nuclease domain in complex with poly(a) dna |
| Resolution | 2.2Å |
| Reference | AUTH H.WANG,M.MORITA,X.YANG,T.SUZUKI,W.YANG,J.WANG,K.ITO,Q.WANG,AUTH 2 C.ZHAO,M.BARTLAM,T.YAMAMOTO,Z.RAOTITL CRYSTAL STRUCTURE OF THE HUMAN CNOT6L NUCLEASE DOMAINTITL 2 REVEALS STRICT POLY(A) SUBSTRATE SPECIFICITY.REF EMBO J. 2010REFN ESSN 1460-2075PMID 20628353DOI 10.1038/EMBOJ.2010.152 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 337 |
| Number Of SNVs | 24 |
| Number Of Permutations | 3078 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.029 |
| p-value | 0.182 |
COSMIC
| Number Of Residues | 337 |
| Number Of SNVs | 4 |
| Number Of Permutations | 57 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.167 |
| p-value | 0.362 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 24 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.583 |
| p-value | 0.072 |