General Structure Information
| PDB ID | 2erx |
| HGNC Gene Label(s) | DIRAS2 |
| Structure Name | crystal structure of diras2 in complex with gdp and inorganic phosphate |
| Resolution | 1.65Å |
| Reference | AUTH E.PAPAGRIGORIOU,X.YANG,J.ELKINS,F.E.NIESEN,AUTH 2 N.BURGESS,E.SALAH,O.FEDOROV,L.J.BALL,F.VON DELFT,AUTH 3 M.SUNDSTROM,A.EDWARDS,C.ARROWSMITH,J.WEIGELT,AUTH 4 D.DOYLETITL CRYSTAL STRUCTURE OF DIRAS2REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 168 |
| Number Of SNVs | 23 |
| Number Of Permutations | 2024 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.146 |
| p-value | 0.034 |
COSMIC
| Number Of Residues | 168 |
| Number Of SNVs | 6 |
| Number Of Permutations | 423 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.067 |
| p-value | 0.775 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 23 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.178 |
| p-value | 0.443 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
