General Structure Information
| PDB ID | 4f52 |
| HGNC Gene Label(s) | GLMN |
| Structure Name | structure of a glomulin-rbx1-cul1 complex |
| Resolution | 3.0Å |
| Reference | AUTH D.M.DUDA,J.L.OLSZEWSKI,A.E.TRON,M.HAMMEL,L.J.LAMBERT,AUTH 2 M.B.WADDELL,T.MITTAG,J.A.DECAPRIO,B.A.SCHULMANTITL STRUCTURE OF A GLOMULIN-RBX1-CUL1 COMPLEX: INHIBITION OF ATITL 2 RING E3 LIGASE THROUGH MASKING OF ITS E2-BINDING SURFACE.REF MOL.CELL V. 47 371 2012REFN ISSN 1097-2765PMID 22748924DOI 10.1016/J.MOLCEL.2012.05.044 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 512 |
| Number Of SNVs | 101 |
| Number Of Permutations | 74572 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.154 |
| p-value | 0.519 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 1:92763549 | V>A | F:3 | (16.16, 34.42, 86.34) | |
| 1:92763541 | L>F | F:6 | (11.43, 31.42, 84.46) | |
| 1:92763537 | Q>R | F:7 | (10.26, 35.69, 86.80) | |
| 1:92763538 | Q>K | F:7 | (10.26, 35.69, 86.80) | |
| 1:92763532 | I>V | F:9 | (7.32, 32.69, 81.47) | |
| 1:92763528 | rs372884627 | I>T | F:10 | (6.30, 33.67, 86.14) |
| 1:92763529 | I>V | F:10 | (6.30, 33.67, 86.14) | |
| 1:92763521 | R>S | F:12 | (3.41, 35.44, 80.51) | |
| 1:92763519 | C>Y | F:13 | (1.51, 33.01, 84.09) | |
| 1:92763086 | rs199998555 | Q>E | F:14 | (1.55, 35.95, 87.89) |
| 1:92763031 | rs200121546 | A>V | F:32 | (14.06, 28.00, 81.98) |
| 1:92763021 | rs373731314 | R>S | F:35 | (17.87, 27.76, 79.96) |
| 1:92762993 | L>V | F:45 | (15.38, 29.02, 92.67) | |
| 1:92762982 | rs142032681 | I>M | F:48 | (9.65, 31.35, 92.50) |
| 1:92762974 | N>S | F:51 | (6.18, 33.33, 96.99) | |
| 1:92757081 | N>S | F:60 | (-1.63, 23.28, 86.39) | |
| 1:92757072 | W>L | F:63 | (5.23, 17.46, 84.38) | |
| 1:92757067 | L>V | F:65 | (11.06, 21.09, 87.10) | |
| 1:92757064 | V>I | F:66 | (10.93, 15.99, 88.44) | |
| 1:92757007 | V>I | F:85 | (18.10, 22.77, 97.84) | |
| 1:92757004 | Y>N | F:86 | (18.75, 20.65, 94.12) | |
| 1:92756994 | I>T | F:89 | (12.75, 22.20, 95.10) | |
| 1:92756988 | D>G | F:91 | (9.57, 17.54, 99.04) | |
| 1:92756989 | rs144577963 | D>N | F:91 | (9.57, 17.54, 99.04) |
| 1:92755861 | L>F | F:96 | (2.13, 22.29, 95.32) | |
| 1:92755835 | rs137912002 | G>V | F:105 | (7.72, 11.62, 85.91) |
| 1:92755836 | rs546478305 | G>C | F:105 | (7.72, 11.62, 85.91) |
| 1:92755800 | rs528326427 | Q>E | F:117 | (21.45, 3.70, 89.15) |
| 1:92755775 | rs371115563 | L>W | F:125 | (11.47, 8.02, 93.32) |
| 1:92755766 | P>R | F:128 | (7.75, 10.22, 96.84) | |
| 1:92755760 | Q>R | F:130 | (3.19, 5.96, 98.82) | |
| 1:92754703 | COSM1748663 | Q>K | F:134 | (-2.37, 8.23, 98.43) |
| 1:92754684 | A>E | F:140 | (-6.03, 1.57, 90.29) | |
| 1:92754685 | A>P | F:140 | (-6.03, 1.57, 90.29) | |
| 1:92754681 | Y>C | F:141 | (-4.01, 3.14, 85.00) | |
| 1:92754672 | G>V | F:144 | (-0.58, -0.78, 88.19) | |
| 1:92754666 | A>V | F:146 | (3.57, 1.32, 89.15) | |
| 1:92754667 | rs61754623 | A>T | F:146 | (3.57, 1.32, 89.15) |
| 1:92754657 | T>I | F:149 | (6.98, 0.20, 86.26) | |
| 1:92754658 | COSM4010606 | T>A | F:149 | (6.98, 0.20, 86.26) |
| 1:92754639 | S>C | F:155 | (12.83, -8.25, 86.30) | |
| 1:92754622 | Y>H | F:161 | (22.71, -16.45, 93.56) | |
| 1:92754600 | M>T | F:168 | (26.48, -7.48, 100.30) | |
| 1:92754601 | rs369660278 | M>V | F:168 | (26.48, -7.48, 100.30) |
| 1:92754591 | Y>C | F:171 | (23.27, -5.06, 90.96) | |
| 1:92754571 | K>E | F:178 | (13.44, -5.17, 102.03) | |
| 1:92754568 | rs569842476 | A>S | F:179 | (10.57, -1.23, 100.20) |
| 1:92754565 | rs375076746 | L>V | F:180 | (8.39, -2.75, 97.16) |
| 1:92754562 | I>V | F:181 | (6.29, -4.67, 101.13) | |
| 1:92754550 | K>Q | F:185 | (1.69, -2.71, 103.55) | |
| 1:92754546 | rs530241354 | P>L | F:186 | (-0.65, 1.24, 102.26) |
| 1:92754543 | COSM913297 | F>S | F:187 | (-1.60, 1.49, 98.52) |
| 1:92754531 | V>D | F:191 | (-8.93, -3.30, 99.78) | |
| 1:92754532 | rs199528216 | V>F | F:191 | (-8.93, -3.30, 99.78) |
| 1:92752122 | L>F | F:220 | (9.91, -15.85, 94.59) | |
| 1:92752118 | T>S | F:222 | (15.51, -17.60, 91.29) | |
| 1:92752114 | A>G | F:223 | (15.40, -18.16, 95.19) | |
| 1:92752082 | N>H | F:234 | (17.94, -10.98, 107.87) | |
| 1:92752077 | D>E | F:235 | (15.92, -14.15, 105.48) | |
| 1:92752070 | R>G | F:238 | (11.11, -16.92, 104.98) | |
| 1:92752061 | A>T | F:241 | (7.14, -14.28, 100.23) | |
| 1:92737209 | G>R | F:246 | (-0.53, -12.16, 102.48) | |
| 1:92737197 | rs112032338 | A>P | F:250 | (-6.00, -10.31, 102.04) |
| 1:92737194 | I>V | F:251 | (-6.97, -9.64, 98.22) | |
| 1:92737186 | H>Q | F:253 | (-8.61, -14.75, 95.67) | |
| 1:92737184 | rs145762716 | P>R | F:254 | (-6.64, -17.30, 99.30) |
| 1:92737103 | Q>P | F:281 | (4.04, -15.89, 81.90) | |
| 1:92737089 | rs139743855 | M>V | F:286 | (1.10, -21.06, 90.91) |
| 1:92737086 | COSM4010605 | A>S | F:287 | (5.49, -23.08, 91.48) |
| 1:92737071 | L>V | F:292 | (7.30, -20.69, 98.94) | |
| 1:92737046 | rs34062020 | I>T | F:300 | (1.19, -24.13, 106.03) |
| 1:92737040 | rs573582566 | Q>R | F:302 | (-3.52, -19.67, 105.27) |
| 1:92737025 | rs200403545 | L>S | F:307 | (-5.64, -32.36, 102.86) |
| 1:92735325 | Y>F | F:311 | (-5.73, -33.23, 96.13) | |
| 1:92735322 | L>P | F:312 | (-1.25, -32.18, 97.73) | |
| 1:92735301 | rs143112068 | H>P | F:319 | (3.57, -27.01, 90.29) |
| 1:92733663 | rs35258161 | L>S | F:336 | (14.33, -32.37, 93.33) |
| 1:92733546 | rs147889200 | N>S | F:341 | (7.80, -32.67, 100.76) |
| 1:92733511 | rs149792649 | Y>H | F:353 | (-3.64, -48.01, 87.30) |
| 1:92733502 | L>V | F:356 | (1.01, -43.08, 84.98) | |
| 1:92733495 | I>T | F:358 | (-1.62, -37.53, 84.70) | |
| 1:92732267 | I>T | F:377 | (25.38, -30.13, 89.88) | |
| 1:92732031 | rs78101774 | M>V | F:387 | (13.87, -38.78, 94.06) |
| 1:92732004 | D>Y | F:396 | (1.00, -49.99, 91.17) | |
| 1:92731997 | Q>R | F:398 | (0.24, -51.62, 86.22) | |
| 1:92731986 | rs374766335 | T>A | F:402 | (4.40, -48.57, 82.66) |
| 1:92730178 | rs367711850 | S>T | F:411 | (16.37, -43.02, 78.02) |
| 1:92730176 | N>H | F:412 | (18.50, -43.36, 74.54) | |
| 1:92730139 | I>T | F:424 | (12.83, -55.50, 86.30) | |
| 1:92730136 | K>R | F:425 | (16.16, -58.41, 89.78) | |
| 1:92729273 | rs376649308 | K>R | F:439 | (1.37, -61.99, 89.31) |
| 1:92729271 | W>R | F:440 | (1.16, -56.37, 85.36) | |
| 1:92729255 | Q>R | F:445 | (2.97, -59.01, 80.50) | |
| 1:92729244 | L>F | F:449 | (9.41, -56.06, 79.64) | |
| 1:92729234 | L>S | F:452 | (12.42, -53.89, 75.68) | |
| 1:92729235 | L>V | F:452 | (12.42, -53.89, 75.68) | |
| 1:92729214 | G>C | F:459 | (24.38, -57.49, 67.29) | |
| 1:92728458 | R>W | F:479 | (23.56, -65.43, 86.76) | |
| 1:92728424 | rs149248328 | N>S | F:490 | (7.42, -72.58, 84.36) |
| 1:92713537 | W>R | F:495 | (13.26, -73.47, 81.17) | |
| 1:92713519 | rs148335800 | I>V | F:501 | (16.62, -65.83, 74.51) |
| 1:92713498 | P>S | F:508 | (24.37, -63.05, 69.09) | |
| 1:92713491 | H>R | F:510 | (29.47, -66.02, 72.21) | |
| 1:92713479 | N>S | F:514 | (34.39, -63.59, 69.07) | |
| 1:92713470 | K>R | F:517 | (38.88, -60.62, 70.65) | |
| 1:92713445 | K>N | F:525 | (49.98, -57.05, 65.57) | |
| 1:92712695 | rs200389652 COSM1738452 |
Q>R | F:531 | (56.15, -49.11, 67.18) |
| 1:92712174 | rs138005763 | D>E | F:566 | (37.41, -60.91, 79.18) |
| 1:92712169 | I>T | F:568 | (30.60, -59.62, 79.13) | |
| 1:92712152 | R>G | F:574 | (27.76, -69.52, 85.49) | |
| 1:92712136 | I>T | F:579 | (21.32, -73.32, 80.80) |