General Structure Information
| PDB ID | 3tmo |
| HGNC Gene Label(s) | OTUD5 |
| Structure Name | the catalytic domain of human deubiquitinase duba |
| Resolution | 2.2Å |
| Reference | AUTH O.W.HUANG,X.MA,J.YIN,J.FLINDERS,T.MAURER,N.KAYAGAKI,Q.PHUNG,AUTH 2 I.BOSANAC,D.ARNOTT,V.M.DIXIT,S.G.HYMOWITZ,M.A.STAROVASNIK,AUTH 3 A.G.COCHRANTITL PHOSPHORYLATION-DEPENDENT ACTIVITY OF THE DEUBIQUITINASETITL 2 DUBA.REF NAT.STRUCT.MOL.BIOL. V. 19 171 2012REFN ISSN 1545-9993PMID 22245969DOI 10.1038/NSMB.2206 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 133 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1610 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.0 |
| p-value | 0.943 |
COSMIC
| Number Of Residues | 133 |
| Number Of SNVs | 4 |
| Number Of Permutations | 188 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.167 |
| p-value | 0.729 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 8 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | -0.333 |
| p-value | 0.437 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
