General Structure Information
| PDB ID | 1l2j |
| HGNC Gene Label(s) | ESR2 |
| Structure Name | human estrogen receptor beta ligand-binding domain in complex with (r, r)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol |
| Resolution | 2.95Å |
| Reference | AUTH A.K.SHIAU,D.BARSTAD,J.T.RADEK,M.J.MEYERS,K.W.NETTLES,AUTH 2 B.S.KATZENELLENBOGEN,J.A.KATZENELLENBOGEN,D.A.AGARD,AUTH 3 G.L.GREENETITL STRUCTURAL CHARACTERIZATION OF A SUBTYPE-SELECTIVE LIGANDTITL 2 REVEALS A NOVEL MODE OF ESTROGEN RECEPTOR ANTAGONISM.REF NAT.STRUCT.BIOL. V. 9 359 2002REFN ISSN 1072-8368PMID 11953755 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 222 |
| Number Of SNVs | 74 |
| Number Of Permutations | 27291 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.024 |
| p-value | 0.967 |
COSMIC
| Number Of Residues | 222 |
| Number Of SNVs | 3 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 74 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.31 |
| p-value | 0.576 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
