General Structure Information
| PDB ID | 2rc4 |
| HGNC Gene Label(s) | KAT6A |
| Structure Name | crystal structure of the hat domain of the human moz protein |
| Resolution | 3.0Å |
| Reference | AUTH M.A.HOLBERT,T.SIKORSKI,J.CARTEN,D.SNOWFLACK,S.HODAWADEKAR,AUTH 2 R.MARMORSTEINTITL THE HUMAN MONOCYTIC LEUKEMIA ZINC FINGER HISTONETITL 2 ACETYLTRANSFERASE DOMAIN CONTAINS DNA-BINDING ACTIVITYTITL 3 IMPLICATED IN CHROMATIN TARGETING.REF J.BIOL.CHEM. V. 282 36603 2007REFN ISSN 0021-9258PMID 17925393DOI 10.1074/JBC.M705812200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 264 |
| Number Of SNVs | 27 |
| Number Of Permutations | 16392 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.117 |
| p-value | 0.522 |
COSMIC
| Number Of Residues | 264 |
| Number Of SNVs | 3 |
| Number Of Permutations | 193 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | 0.333 |
| p-value | 0.511 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 27 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | -0.496 |
| p-value | 0.206 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
