General Structure Information
| PDB ID | 2wjv |
| HGNC Gene Label(s) | UPF1 |
| Structure Name | crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2 |
| Resolution | 2.85Å |
| Reference | AUTH M.CLERICI,A.MOURAO,I.GUTSCHE,N.H.GEHRING,M.W.HENTZE,AUTH 2 A.KULOZIK,J.KADLEC,M.SATTLER,S.CUSACKTITL UNUSUAL BIPARTITE MODE OF INTERACTION BETWEEN THETITL 2 NONSENSE-MEDIATED DECAY FACTORS, UPF1 AND UPF2.REF EMBO J. V. 28 2293 2009REFN ISSN 0261-4189PMID 19556969DOI 10.1038/EMBOJ.2009.175 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 772 |
| Number Of SNVs | 84 |
| Number Of Permutations | 33598 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | 0.292 |
| p-value | 0.032 |
COSMIC
| Number Of Residues | 772 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1732 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.1 |
| p-value | 0.811 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 84 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.229 |
| p-value | 0.577 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
