General Structure Information
| PDB ID | 3f70 |
| HGNC Gene Label(s) | L3MBTL2 |
| Structure Name | crystal structure of l3mbtl2-h4k20me1 complex |
| Resolution | 2.1Å |
| Reference | AUTH Y.GUO,N.NADY,C.QI,A.ALLALI-HASSANI,H.ZHU,P.PAN,AUTH 2 M.A.ADAMS-CIOABA,M.F.AMAYA,A.DONG,M.VEDADI,M.SCHAPIRA,AUTH 3 R.J.READ,C.H.ARROWSMITH,J.MINTITL METHYLATION-STATE-SPECIFIC RECOGNITION OF HISTONES BY THETITL 2 MBT REPEAT PROTEIN L3MBTL2.REF NUCLEIC ACIDS RES. V. 37 2204 2009REFN ISSN 0305-1048PMID 19233876DOI 10.1093/NAR/GKP086 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 392 |
| Number Of SNVs | 84 |
| Number Of Permutations | 24527 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.378 |
| p-value | 0.69 |
COSMIC
| Number Of Residues | 392 |
| Number Of SNVs | 4 |
| Number Of Permutations | 71 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.167 |
| p-value | 0.013 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 84 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.166 |
| p-value | 0.005 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
