2ZIV.B | EME1 – ASTRID

2ZIV.B | EME1

General Structure Information

PDB ID	2ziv
HGNC Gene Label(s)	EME1
Structure Name	crystal structure of the mus81-eme1 complex
Resolution	2.7Å
Reference	AUTH J.H.CHANG,J.J.KIM,J.M.CHOI,J.H.LEE,Y.CHOTITL CRYSTAL STRUCTURE OF THE MUS81-EME1 COMPLEXREF GENES DEV. V. 22 1093 2008REFN ISSN 0890-9369PMID 18413719DOI 10.1101/GAD.1618708

Variant Set Distributions

ExAC Variants

Number Of Residues	269
Number Of SNVs	77
Number Of Permutations	52164
Optimal Distance Threshold	13.0
K Statistic	0.093
p-value	0.532

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
17:48453328	rs529245469	I>M	B:253	(-25.49, 4.27, 70.67)
17:48453429	rs184924405	L>F	B:260	(-24.01, 7.82, 55.14)
17:48453436		Q>R	B:262	(-25.40, 3.56, 50.08)
17:48453445	COSM189409	G>V	B:265	(-16.94, 6.26, 52.70)
17:48453454		Q>R	B:268	(-13.21, 4.87, 55.50)
17:48453485	rs377398681	C>W	B:278	(-19.00, 2.41, 69.72)
17:48453496	rs368542094	I>T	B:282	(-27.86, 0.71, 60.44)
17:48453502	rs140871641	A>V	B:284	(-33.77, 5.64, 59.01)
17:48453513		P>S	B:288	(-31.65, 12.14, 54.79)
17:48453514		P>L	B:288	(-31.65, 12.14, 54.79)
17:48453519	rs147953616	S>G	B:290	(-27.80, 11.40, 59.18)
17:48455967		D>E	B:305	(-34.01, 2.69, 77.54)
17:48455971	rs534792200	V>M	B:307	(-31.04, 8.83, 75.83)
17:48455978		E>V	B:309	(-27.17, 12.78, 72.95)
17:48455980		P>A	B:310	(-28.50, 16.32, 71.35)
17:48455986		V>I	B:312	(-27.35, 16.20, 64.22)
17:48456001	rs368608565	R>W	B:317	(-22.87, 14.01, 47.97)
17:48456002	rs150290882	R>Q	B:317	(-22.87, 14.01, 47.97)
17:48456004		A>S	B:318	(-20.25, 19.23, 46.64)
17:48456019		S>T	B:323	(-26.99, 23.97, 44.17)
17:48456020		S>F	B:323	(-26.99, 23.97, 44.17)
17:48456028	rs117096984	D>N	B:326	(-25.65, 27.51, 41.91)
17:48456030		D>E	B:326	(-25.65, 27.51, 41.91)
17:48456169		T>M	B:342	(-33.86, 24.91, 47.43)
17:48456183	rs7222520	V>I	B:347	(-30.91, 24.15, 57.03)
17:48456193	rs12450550	I>T	B:350	(-32.40, 19.95, 58.49)
17:48456196	rs143055740	T>I	B:351	(-34.15, 22.28, 62.02)
17:48456198		A>T	B:352	(-37.92, 20.62, 61.49)
17:48456199		A>V	B:352	(-37.92, 20.62, 61.49)
17:48456569	rs200188162	R>T	B:405	(-11.69, 29.17, 48.75)
17:48456577		A>T	B:408	(-18.54, 29.67, 50.19)
17:48456814	rs367866395	A>V	B:411	(-22.75, 31.00, 52.24)
17:48456817		L>S	B:412	(-20.77, 29.13, 55.00)
17:48456844		A>V	B:421	(-25.66, 25.77, 61.95)
17:48456849	rs138109548	A>T	B:423	(-20.11, 24.38, 58.97)
17:48456858		V>M	B:426	(-14.05, 17.62, 54.17)
17:48456884	rs372248513	D>E	B:434	(-10.60, 10.99, 61.53)
17:48456885	rs142635770	F>L	B:435	(-15.31, 15.46, 62.36)
17:48456918		A>T	B:446	(-22.51, 16.23, 78.08)
17:48456919		A>V	B:446	(-22.51, 16.23, 78.08)
17:48457681	rs150592663	R>Q	B:452	(-25.47, 27.29, 82.05)
17:48457686	rs139232217	E>Q	B:454	(-18.63, 26.72, 86.31)
17:48457688	COSM3889883	E>D	B:454	(-18.63, 26.72, 86.31)
17:48457695		F>L	B:457	(-12.68, 27.36, 93.37)
17:48457699		S>Y	B:458	(-15.34, 25.15, 90.03)
17:48457722	rs77309724	A>P	B:466	(-1.53, 19.52, 81.33)
17:48457731		V>L	B:469	(4.23, 16.37, 87.06)
17:48457744		L>R	B:473	(9.25, 8.22, 96.03)
17:48457749		G>S	B:475	(11.25, 14.16, 94.00)
17:48457754		R>S	B:476	(13.86, 11.86, 91.37)
17:48457756		G>E	B:477	(9.94, 16.66, 89.32)
17:48457774		R>M	B:483	(7.84, 25.29, 84.96)
17:48457781		Q>H	B:485	(3.17, 25.72, 91.11)
17:48457783		I>T	B:486	(4.93, 30.11, 88.90)
17:48457785		Q>E	B:487	(3.48, 28.19, 84.11)
17:48457816	rs376122157	A>V	B:497	(8.95, 30.79, 85.03)
17:48457819	rs140855447	S>N	B:498	(12.15, 29.57, 84.10)
17:48457833		A>T	B:503	(16.39, 32.18, 91.08)
17:48457837		Y>C	B:504	(14.51, 32.74, 94.07)
17:48457845		P>A	B:507	(9.32, 26.96, 97.49)
17:48458125	COSM3362439	A>V	B:513	(13.80, 36.01, 100.28)
17:48458130	rs147937060	Q>E	B:515	(11.73, 36.13, 105.61)
17:48458143	rs140102116	S>L	B:519	(10.28, 46.17, 102.64)
17:48458148		K>E	B:521	(8.95, 48.43, 98.24)
17:48458151	rs368387483	E>K	B:522	(12.68, 44.96, 99.22)
17:48458154		R>S	B:523	(9.16, 41.78, 101.26)
17:48458155		R>H	B:523	(9.16, 41.78, 101.26)
17:48458173		D>A	B:529	(14.96, 43.66, 88.01)
17:48458175		I>V	B:530	(14.30, 38.58, 87.04)
17:48458178		Q>E	B:531	(16.13, 39.93, 82.37)
17:48458184	rs61023979	R>C	B:533	(17.11, 33.31, 77.28)
17:48458185	rs201414369	R>H	B:533	(17.11, 33.31, 77.28)
17:48458187	COSM4067603	R>C	B:534	(19.41, 36.55, 83.69)
17:48458190		G>W	B:535	(23.58, 34.61, 79.39)
17:48458191		G>A	B:535	(23.58, 34.61, 79.39)
17:48458193	rs371711162	E>K	B:536	(21.92, 35.40, 75.97)
17:48458214	rs150098713	R>C	B:543	(13.01, 43.31, 79.22)
17:48458215		R>H	B:543	(13.01, 43.31, 79.22)
17:48458217	rs374946869	R>C	B:544	(11.57, 44.05, 83.72)
17:48458221		I>T	B:545	(9.46, 39.69, 85.36)
17:48458229		E>Q	B:548	(2.06, 42.98, 87.89)
17:48458239	rs566079135	R>K	B:551	(1.83, 43.21, 93.83)
17:48458241	rs61745952	R>C	B:552	(0.54, 38.67, 90.21)
17:48458263		T>I	B:559	(-1.52, 35.85, 101.69)
17:48458271		P>S	B:562	(-8.00, 33.06, 100.84)
17:48458284	rs528576282	L>S	B:566	(-4.00, 38.42, 92.52)
17:48458286		D>H	B:567	(-5.14, 42.82, 90.94)
17:48458289	rs568424837	S>R	B:568	(-3.26, 46.54, 90.91)