General Structure Information
| PDB ID | 2ovq |
| HGNC Gene Label(s) | FBXW7 |
| Structure Name | structure of the skp1-fbw7-cyclinedegc complex |
| Resolution | 2.6Å |
| Reference | AUTH B.HAO,S.OEHLMANN,M.E.SOWA,J.W.HARPER,N.P.PAVLETICHTITL STRUCTURE OF A FBW7-SKP1-CYCLIN E COMPLEX:TITL 2 MULTISITE-PHOSPHORYLATED SUBSTRATE RECOGNITION BY SCFTITL 3 UBIQUITIN LIGASESREF MOL.CELL V. 26 131 2007REFN ISSN 1097-2765PMID 17434132DOI 10.1016/J.MOLCEL.2007.02.022 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 444 |
| Number Of SNVs | 31 |
| Number Of Permutations | 25917 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.006 |
| p-value | 0.599 |
COSMIC
| Number Of Residues | 444 |
| Number Of SNVs | 37 |
| Number Of Permutations | 45482 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.086 |
| p-value | 0.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 31 |
| Number Of COSMIC SNVs | 23 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.069 |
| p-value | 0.003 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
