General Structure Information
| PDB ID | 2ylm |
| HGNC Gene Label(s) | USP7 |
| Structure Name | mechanism of usp7 (hausp) activation by its c-terminal ubiquitin-like domain (hubl) and allosteric regulation by gmp-synthetase. |
| Resolution | 2.7Å |
| Reference | AUTH A.C.FAESEN,A.M.G.DIRAC,A.SHANMUGHAM,H.OVAA,A.PERRAKIS,AUTH 2 T.K.SIXMATITL MECHANISM OF USP7/HAUSP ACTIVATION BY ITS C- TERMINALTITL 2 UBIQUITIN-LIKE DOMAIN AND ALLOSTERIC REGULATION BYTITL 3 GMP-SYNTHETASEREF MOL.CELL V. 44 147 2011REFN ISSN 1097-2765PMID 21981925DOI 10.1016/J.MOLCEL.2011.06.034 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 524 |
| Number Of SNVs | 63 |
| Number Of Permutations | 23692 |
| Optimal Distance Threshold | 34.0 |
| K Statistic | 0.323 |
| p-value | 0.13 |
COSMIC
| Number Of Residues | 524 |
| Number Of SNVs | 5 |
| Number Of Permutations | 5812 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.1 |
| p-value | 0.432 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
