General Structure Information
| PDB ID | 3aj4 |
| HGNC Gene Label(s) | PLEKHB2 |
| Structure Name | crystal structure of the ph domain of evectin-2 from human complexed with o-phospho-l-serine |
| Resolution | 1.0Å |
| Reference | AUTH Y.UCHIDA,J.HASEGAWA,D.CHINNAPEN,T.INOUE,S.OKAZAKI,R.KATO,AUTH 2 S.WAKATSUKI,R.MISAKI,M.KOIKE,Y.UCHIYAMA,S.IEMURA,T.NATSUME,AUTH 3 R.KUWAHARA,T.NAKAGAWA,K.NISHIKAWA,K.MUKAI,E.MIYOSHI,AUTH 4 N.TANIGUCHI,D.SHEFF,W.I.LENCER,T.TAGUCHI,H.ARAITITL INTRACELLULAR PHOSPHATIDYLSERINE IS ESSENTIAL FOR RETROGRADETITL 2 MEMBRANE TRAFFIC THROUGH ENDOSOMESREF PROC.NATL.ACAD.SCI.USA V. 108 15846 2011REFN ISSN 0027-8424PMID 21911378DOI 10.1073/PNAS.1109101108 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 110 |
| Number Of SNVs | 28 |
| Number Of Permutations | 6937 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.0 |
| p-value | 0.283 |
COSMIC
| Number Of Residues | 110 |
| Number Of SNVs | 3 |
| Number Of Permutations | 66 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.667 |
| p-value | 0.059 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
