4FP9.D | NSUN4

General Structure Information

PDB ID	4fp9
HGNC Gene Label(s)	NSUN4
Structure Name	human mterf4-nsun4 protein complex
Resolution	2.9Å
Reference	AUTH H.SPAHR,B.HABERMANN,C.M.GUSTAFSSON,N.G.LARSSON,B.M.HALLBERGTITL STRUCTURE OF THE HUMAN MTERF4-NSUN4 PROTEIN COMPLEX THATTITL 2 REGULATES MITOCHONDRIAL RIBOSOME BIOGENESIS.REF PROC.NATL.ACAD.SCI.USA V. 109 15253 2012REFN ISSN 0027-8424PMID 22949673DOI 10.1073/PNAS.1210688109

Variant Set Distributions

ExAC Variants

Number Of Residues	333
Number Of SNVs	81
Number Of Permutations	9487
Optimal Distance Threshold	17.0
K Statistic	0.211
p-value	0.738

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
1:46810504		R>P	D:42	(102.89, 116.42, 36.57)
1:46810507		L>P	D:43	(103.83, 117.82, 42.55)
1:46810509		A>S	D:44	(99.28, 116.91, 43.31)
1:46810530	rs3737744	T>A	D:51	(98.23, 109.01, 49.44)
1:46810531		T>I	D:51	(98.23, 109.01, 49.44)
1:46810539		V>M	D:54	(96.97, 103.31, 49.96)
1:46810545		F>V	D:56	(90.50, 105.46, 48.60)
1:46810548		G>R	D:57	(92.60, 101.30, 45.99)
1:46810559	rs370996941	W>C	D:60	(92.94, 107.03, 43.10)
1:46810561		P>L	D:61	(90.82, 104.49, 39.77)
1:46810564		S>L	D:62	(86.98, 106.03, 40.12)
1:46810566		I>V	D:63	(88.33, 108.87, 42.71)
1:46810569	rs112451233	R>C	D:64	(93.61, 109.64, 38.52)
1:46810570	rs140936833	R>H	D:64	(93.61, 109.64, 38.52)
1:46810573		V>A	D:65	(88.60, 109.86, 36.21)
1:46810593		K>E	D:72	(77.58, 117.11, 39.10)
1:46810597		Y>C	D:73	(78.95, 122.57, 39.37)
1:46810605		L>M	D:76	(71.53, 127.01, 46.57)
1:46810633		H>R	D:85	(58.39, 131.56, 40.32)
1:46810666		K>R	D:96	(65.25, 116.44, 39.99)
1:46810684		A>V	D:102	(66.05, 113.16, 51.14)
1:46810689		S>A	D:104	(60.89, 112.22, 51.61)
1:46810756		S>I	D:126	(69.31, 121.98, 58.04)
1:46810768	COSM3490303	R>P	D:130	(64.68, 125.11, 48.81)
1:46810777		T>I	D:133	(70.83, 118.18, 40.90)
1:46810797	rs138645617	S>G	D:140	(73.76, 118.97, 32.21)
1:46810800		R>C	D:141	(77.36, 122.91, 31.50)
1:46810801	rs570242195 COSM246121	R>H	D:141	(77.36, 122.91, 31.50)
1:46810809		P>S	D:144	(74.41, 131.58, 34.23)
1:46810815	rs145301228	R>G	D:146	(71.30, 135.85, 35.08)
1:46812607		G>V	D:151	(68.06, 142.10, 42.89)
1:46812633		A>P	D:160	(76.39, 119.62, 46.15)
1:46812636		A>S	D:161	(78.56, 118.35, 48.75)
1:46812644		L>F	D:163	(74.60, 121.83, 51.12)
1:46812663	rs375507367	G>S	D:170	(71.16, 121.18, 62.46)
1:46812675		G>R	D:174	(67.51, 130.53, 67.05)
1:46812684	rs368239992	V>M	D:177	(75.62, 130.38, 63.89)
1:46812685		V>A	D:177	(75.62, 130.38, 63.89)
1:46812697		C>Y	D:181	(86.57, 129.24, 57.92)
1:46812703		A>V	D:183	(85.62, 132.26, 52.74)
1:46812708	rs372410507 COSM1259609	G>R	D:185	(80.33, 131.87, 51.19)
1:46812709		G>E	D:185	(80.33, 131.87, 51.19)
1:46812712		G>E	D:186	(78.70, 129.26, 50.50)
1:46812738		G>C	D:195	(66.06, 130.86, 58.97)
1:46812739		G>A	D:195	(66.06, 130.86, 58.97)
1:46812747	rs147331351	R>C	D:198	(69.56, 135.31, 67.85)
1:46818560		L>F	D:205	(92.84, 135.22, 58.34)
1:46818567		P>L	D:207	(91.22, 140.31, 53.88)
1:46818579	rs200170006	A>V	D:211	(85.38, 140.64, 49.63)
1:46818581	COSM3728206	R>G	D:212	(85.43, 135.90, 46.92)
1:46818584	rs534371705	L>V	D:213	(81.70, 136.84, 52.08)
1:46818603		S>I	D:219	(74.55, 139.41, 45.37)
1:46818608	rs370208294	V>M	D:221	(71.46, 139.00, 51.16)
1:46818642	rs112773776	R>Q	D:232	(80.14, 139.05, 63.61)
1:46818662		R>G	D:239	(94.69, 129.69, 65.33)
1:46818665		K>Q	D:240	(93.21, 133.03, 68.88)
1:46818699		R>Q	D:251	(74.20, 124.35, 65.95)
1:46826382		V>M	D:254	(85.14, 124.13, 61.17)
1:46826383		V>A	D:254	(85.14, 124.13, 61.17)
1:46826406	rs375216448 COSM910314	R>C	D:262	(88.25, 118.60, 41.80)
1:46826407	rs201711075 COSM910315	R>H	D:262	(88.25, 118.60, 41.80)
1:46826413	rs138059029	S>F	D:264	(95.17, 121.47, 43.43)
1:46826418		H>Y	D:266	(91.91, 121.94, 37.95)
1:46826439		F>V	D:273	(100.69, 120.14, 46.49)
1:46826445		R>W	D:275	(109.03, 124.86, 44.01)
1:46826446	rs200276570	R>Q	D:275	(109.03, 124.86, 44.01)
1:46826452		R>K	D:277	(102.40, 126.83, 49.58)
1:46826456		K>N	D:278	(106.89, 120.84, 51.54)
1:46826491		Q>R	D:290	(95.28, 125.01, 65.93)
1:46826500		A>V	D:293	(89.44, 123.52, 68.96)
1:46827249	rs201345631	L>F	D:296	(84.82, 122.59, 69.87)
1:46827262	rs150871361	K>R	D:300	(76.45, 127.01, 73.86)
1:46827274	rs150001344	H>R	D:304	(75.68, 120.32, 68.22)
1:46827279		V>F	D:306	(80.37, 120.46, 61.38)
1:46827283	rs563214814	Y>C	D:307	(86.45, 119.19, 60.34)
1:46827286		S>F	D:308	(84.78, 120.45, 56.84)
1:46827304		H>R	D:314	(92.25, 109.37, 55.82)
1:46827315		E>K	D:318	(89.52, 110.63, 59.74)
1:46827328		Q>R	D:322	(90.97, 111.14, 65.89)
1:46827337	rs13374337	I>T	D:325	(88.32, 115.05, 70.58)
1:46827342		L>V	D:327	(93.61, 119.40, 72.55)
1:46827352		N>S	D:330	(94.09, 116.13, 77.51)
1:46827408		M>L	D:349	(74.09, 106.83, 49.55)
1:46827430		S>L	D:356	(81.24, 103.58, 53.83)
1:46827438	rs371735371	Q>K	D:359	(86.13, 104.49, 61.22)
1:46827456	rs9865	I>V	D:365	(83.90, 109.59, 46.80)
1:46827463		N>S	D:367	(81.69, 108.80, 40.42)
1:46827472	rs551888089	A>G	D:370	(78.42, 111.84, 40.89)
1:46827495		C>S	D:378	(82.26, 115.40, 61.52)
1:46827504	COSM4008587	R>C	D:381	(76.30, 117.10, 72.04)
1:46827505		R>H	D:381	(76.30, 117.10, 72.04)