General Structure Information
| PDB ID | 4n4f |
| HGNC Gene Label(s) | CREBBP |
| Structure Name | crystal structure of the bromodomain-phd finger module of human transcriptional co-activator cbp in complex with di-acetylated histone 4 peptide (h412ack16ac). |
| Resolution | 1.83Å |
| Reference | AUTH A.N.PLOTNIKOV,S.YANG,T.J.ZHOU,E.RUSINOVA,A.FRASCA,M.M.ZHOUTITL STRUCTURAL INSIGHTS INTO ACETYLATED-HISTONE H4 RECOGNITIONTITL 2 BY THE BROMODOMAIN-PHD FINGER MODULE OF HUMANTITL 3 TRANSCRIPTIONAL COACTIVATOR CBP.REF STRUCTURE V. 22 353 2014REFN ISSN 0969-2126PMID 24361270DOI 10.1016/J.STR.2013.10.021 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 191 |
| Number Of SNVs | 25 |
| Number Of Permutations | 3785 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.507 |
| p-value | 0.008 |
ClinVar
| Number Of Residues | 191 |
| Number Of SNVs | 4 |
| Number Of Permutations | 377 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.333 |
| p-value | 0.044 |
COSMIC
| Number Of Residues | 191 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1110 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.2 |
| p-value | 0.779 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 25 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.287 |
| p-value | 0.074 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 25 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | -0.047 |
| p-value | 0.744 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
