General Structure Information
| PDB ID | 3k2i |
| HGNC Gene Label(s) | ACOT4 |
| Structure Name | human acyl-coenzyme a thioesterase 4 |
| Resolution | 2.4Å |
| Reference | AUTH M.I.SIPONEN,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,P.KRAULIS,T.KOTENYOVA,AUTH 5 A.KOTZSCH,N.MARKOVA,T.K.NIELSEN,P.NORDLUND,T.NYMAN,AUTH 6 C.PERSSON,A.K.ROOS,P.SCHUTZ,L.SVENSSON,AUTH 7 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,AUTH 8 E.WAHLBERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,H.SCHULERTITL HUMAN ACYL-COENZYME A THIOESTERASE 4REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 405 |
| Number Of SNVs | 107 |
| Number Of Permutations | 23916 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.028 |
| p-value | 0.872 |
COSMIC
| Number Of Residues | 405 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1421 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.167 |
| p-value | 0.408 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 107 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.089 |
| p-value | 0.62 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
