General Structure Information
| PDB ID | 4geb |
| HGNC Gene Label(s) | AADAT |
| Structure Name | kynurenine aminotransferase ii inhibitors |
| Resolution | 2.15Å |
| Reference | AUTH A.B.DOUNAY,M.ANDERSON,B.M.BECHLE,E.EVRARD,X.GAN,J.Y.KIM,AUTH 2 L.A.MCALLISTER,J.PANDIT,S.RONG,M.A.SALAFIA,J.B.TUTTLE,AUTH 3 L.E.ZAWADZKE,P.R.VERHOESTTITL PF-04859989 AS A TEMPLATE FOR STRUCTURE-BASED DRUG DESIGN:TITL 2 IDENTIFICATION OF NEW PYRAZOLE SERIES OF IRREVERSIBLE KAT IITITL 3 INHIBITORS WITH IMPROVED LIPOPHILIC EFFICIENCY.REF BIOORG.MED.CHEM.LETT. V. 23 1961 2013REFN ISSN 0960-894XPMID 23466229DOI 10.1016/J.BMCL.2013.02.039 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 425 |
| Number Of SNVs | 58 |
| Number Of Permutations | 17564 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.024 |
| p-value | 0.284 |
COSMIC
| Number Of Residues | 425 |
| Number Of SNVs | 3 |
| Number Of Permutations | 159 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.667 |
| p-value | 0.049 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 58 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.791 |
| p-value | 0.043 |