General Structure Information
| PDB ID | 4da1 |
| HGNC Gene Label(s) | PPM1K |
| Structure Name | crystal structure of branched-chain alpha-ketoacid dehydrogenase phosphatase with mg (ii) ions at the active site |
| Resolution | 2.38Å |
| Reference | AUTH R.M.WYNN,J.LI,C.A.BRAUTIGAM,J.L.CHUANG,D.T.CHUANGTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMANTITL 2 MITOCHONDRIAL BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASETITL 3 PHOSPHATASE.REF J.BIOL.CHEM. V. 287 9178 2012REFN ISSN 0021-9258PMID 22291014DOI 10.1074/JBC.M111.314963 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 257 |
| Number Of SNVs | 62 |
| Number Of Permutations | 25205 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.036 |
| p-value | 0.44 |
COSMIC
| Number Of Residues | 257 |
| Number Of SNVs | 4 |
| Number Of Permutations | 385 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.333 |
| p-value | 0.003 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.312 |
| p-value | 0.498 |