General Structure Information
| PDB ID | 3dgc |
| HGNC Gene Label(s) | IL22RA1 |
| Structure Name | structure of il-22/il-22r1 |
| Resolution | 2.5Å |
| Reference | AUTH B.C.JONES,N.J.LOGSDON,M.R.WALTERTITL STRUCTURE OF IL-22 BOUND TO ITS HIGH-AFFINITY IL-22R1 CHAIN.REF STRUCTURE V. 16 1333 2008REFN ISSN 0969-2126PMID 18599299DOI 10.1016/J.STR.2008.06.005 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 207 |
| Number Of SNVs | 64 |
| Number Of Permutations | 15722 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.214 |
| p-value | 0.389 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 1:24465187 | rs569388945 | P>A | S:21 | (70.96, 1.72, -2.09) |
| 1:24465183 | rs200694251 | S>L | S:22 | (72.80, 3.95, 0.91) |
| 1:24465174 | L>P | S:25 | (69.46, 7.76, -1.81) | |
| 1:24465170 | rs199595121 COSM3689487 |
Q>H | S:26 | (70.88, 8.45, 2.93) |
| 1:24465136 | I>F | S:38 | (58.52, 19.43, 0.73) | |
| 1:24465122 | COSM3984901 | D>E | S:42 | (70.32, 13.16, 2.23) |
| 1:24465123 | D>G | S:42 | (70.32, 13.16, 2.23) | |
| 1:24465114 | rs547629990 | P>L | S:45 | (78.80, 7.96, 0.43) |
| 1:24465099 | D>V | S:50 | (77.19, 15.39, -11.47) | |
| 1:24465096 | rs568392040 | T>M | S:51 | (73.87, 12.97, -8.58) |
| 1:24465094 | V>I | S:52 | (70.61, 12.94, -11.32) | |
| 1:24465085 | rs549690226 | I>F | S:55 | (60.70, 12.18, -8.01) |
| 1:24465072 | rs377058116 | T>M | S:59 | (47.87, 6.49, -3.80) |
| 1:24463780 | COSM1666234 | V>M | S:66 | (52.95, 9.13, -10.97) |
| 1:24463753 | COSM3804606 | T>A | S:75 | (70.75, 18.64, -8.97) |
| 1:24463749 | R>Q | S:76 | (66.03, 20.11, -7.00) | |
| 1:24463750 | rs200815886 | R>W | S:76 | (66.03, 20.11, -7.00) |
| 1:24463745 | rs148516044 | K>N | S:77 | (69.08, 17.34, -2.15) |
| 1:24463743 | rs376646024 | S>F | S:78 | (64.01, 19.13, -2.96) |
| 1:24463737 | rs149856921 | N>S | S:80 | (56.64, 20.76, -3.95) |
| 1:24463734 | L>P | S:81 | (54.95, 16.33, -3.89) | |
| 1:24463731 | T>M | S:82 | (51.76, 20.13, -2.20) | |
| 1:24463722 | rs573375692 | T>M | S:85 | (49.91, 15.11, -1.63) |
| 1:24463705 | rs144035143 | L>F | S:91 | (47.50, 7.78, 2.76) |
| 1:24463701 | Y>S | S:92 | (49.60, 10.29, -0.74) | |
| 1:24463687 | T>A | S:97 | (65.69, 7.49, -8.79) | |
| 1:24463683 | A>V | S:98 | (69.59, 7.99, -8.17) | |
| 1:24463684 | A>T | S:98 | (69.59, 7.99, -8.17) | |
| 1:24463674 | rs147985725 | A>V | S:101 | (77.13, 9.99, -14.42) |
| 1:24463668 | G>V | S:103 | (74.98, 4.82, -14.07) | |
| 1:24463665 | rs143430940 | R>Q | S:104 | (75.48, 3.38, -8.73) |
| 1:24463666 | rs374892261 | R>W | S:104 | (75.48, 3.38, -8.73) |
| 1:24463657 | T>A | S:107 | (65.54, 3.37, -5.12) | |
| 1:24463650 | M>K | S:109 | (60.25, 4.17, -0.66) | |
| 1:24463629 | rs371446595 | L>P | S:116 | (45.82, 15.06, 8.47) |
| 1:24460866 | rs546637044 | K>N | S:122 | (53.05, 27.72, 9.65) |
| 1:24460856 | rs534408154 | V>M | S:126 | (48.09, 37.99, 14.29) |
| 1:24460845 | rs375443785 | I>M | S:129 | (44.75, 46.72, 16.98) |
| 1:24460847 | rs144874898 | I>V | S:129 | (44.75, 46.72, 16.98) |
| 1:24460844 | rs34900099 | S>P | S:130 | (46.47, 49.44, 20.28) |
| 1:24460838 | V>M | S:132 | (43.29, 53.66, 25.58) | |
| 1:24460829 | I>V | S:135 | (44.89, 45.05, 23.40) | |
| 1:24460819 | rs190183581 | I>T | S:138 | (42.48, 40.52, 14.18) |
| 1:24460816 | rs569579760 | V>A | S:139 | (42.95, 35.88, 13.55) |
| 1:24460811 | COSM3486384 | P>S | S:141 | (42.55, 34.05, 7.31) |
| 1:24460805 | rs551283023 COSM3966423 |
P>T | S:143 | (45.91, 30.26, 3.44) |
| 1:24460799 | P>T | S:145 | (47.97, 24.21, -0.39) | |
| 1:24460792 | R>H | S:147 | (43.40, 24.21, -4.45) | |
| 1:24460793 | COSM1687214 | R>C | S:147 | (43.40, 24.21, -4.45) |
| 1:24460790 | A>T | S:148 | (38.39, 22.22, -3.28) | |
| 1:24460787 | G>S | S:149 | (36.07, 21.49, -5.56) | |
| 1:24460784 | rs371037428 | D>N | S:150 | (35.37, 25.13, -5.50) |
| 1:24460774 | COSM1501922 COSM679593 |
R>Q | S:153 | (44.51, 27.98, -1.84) |
| 1:24460775 | R>W | S:153 | (44.51, 27.98, -1.84) | |
| 1:24460771 | COSM1340837 | L>P | S:154 | (40.95, 24.72, 1.86) |
| 1:24460763 | rs201248903 | E>K | S:157 | (38.92, 27.54, 10.50) |
| 1:24460721 | rs147757191 | V>F | S:171 | (50.65, 42.16, 32.62) |
| 1:24460714 | rs182225673 | R>H | S:173 | (57.81, 38.13, 36.26) |
| 1:24454737 | F>L | S:188 | (42.63, 40.97, 25.90) | |
| 1:24454733 | rs185047620 | G>S | S:190 | (41.25, 46.52, 31.58) |
| 1:24454729 | L>P | S:191 | (43.99, 47.38, 29.77) | |
| 1:24454699 | rs544118695 | I>T | S:201 | (48.26, 34.15, 19.52) |
| 1:24454688 | rs16829204 | V>I | S:205 | (43.92, 20.81, 16.71) |
| 1:24454681 | T>I | S:207 | (41.25, 15.91, 16.86) | |
| 1:24454676 | rs34379702 | A>S | S:209 | (47.19, 17.00, 19.06) |
| 1:24454673 | K>Q | S:210 | (48.06, 19.34, 15.59) | |
| 1:24454664 | A>T | S:213 | (53.96, 28.18, 17.53) | |
| 1:24454661 | P>A | S:214 | (53.69, 30.77, 19.78) | |
| 1:24454648 | rs144915672 | R>Q | S:218 | (55.82, 42.83, 23.65) |
| 1:24454636 | rs34782294 | L>P | S:222 | (46.92, 54.40, 23.03) |
| 1:24449910 | R>Q | S:225 | (41.66, 64.49, 26.63) |