4M7H.B | FIBCD1

General Structure Information

PDB ID	4m7h
HGNC Gene Label(s)	FIBCD1
Structure Name	crystal structure of tetrameric fibrinogen-like recognition domain of fibcd1
Resolution	2.0Å
Reference	AUTH A.K.SHRIVE,J.B.MOELLER,I.BURNS,J.M.PATERSON,A.J.SHAW,AUTH 2 A.SCHLOSSER,G.L.SORENSEN,T.J.GREENHOUGH,U.HOLMSKOVTITL CRYSTAL STRUCTURE OF THE TETRAMERIC FIBRINOGEN-LIKETITL 2 RECOGNITION DOMAIN OF FIBRINOGEN C DOMAIN CONTAINING 1TITL 3 (FIBCD1) PROTEIN.REF J.BIOL.CHEM. V. 289 2880 2014REFN ISSN 0021-9258PMID 24293368DOI 10.1074/JBC.M113.520577

Variant Set Distributions

ExAC Variants

Number Of Residues	219
Number Of SNVs	79
Number Of Permutations	7414
Optimal Distance Threshold	6.0
K Statistic	0.022
p-value	0.754

COSMIC

Number Of Residues	219
Number Of SNVs	4
Number Of Permutations	16
Optimal Distance Threshold	14.0
K Statistic	0.167
p-value	1.0

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	79
Number Of COSMIC SNVs	4
Optimal Distance Threshold	23.0
K Statistic	0.246
p-value	0.852

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:133799261	rs372531442 COSM1739537	R>Q	B:240	(57.91, 50.99, 7.05)
9:133799262		R>W	B:240	(57.91, 50.99, 7.05)
9:133799259		P>S	B:241	(56.40, 45.80, 7.05)
9:133799255		R>Q	B:242	(51.55, 48.16, 7.55)
9:133799241	rs377553738	V>I	B:247	(56.51, 39.99, 5.75)
9:133799228	rs368578219	G>E	B:251	(58.60, 36.91, 0.19)
9:133799229		G>R	B:251	(58.60, 36.91, 0.19)
9:133799219		D>G	B:254	(61.15, 31.34, 6.11)
9:133799217		D>N	B:255	(58.88, 30.48, 10.22)
9:133799211	rs571770324	V>I	B:257	(62.56, 37.42, 13.76)
9:133799207		Y>C	B:258	(60.69, 38.45, 9.82)
9:133799202		V>L	B:260	(56.99, 45.15, 12.17)
9:133799183	rs192736760	P>L	B:266	(56.54, 54.59, 13.73)
9:133799155		M>I	B:275	(55.11, 32.50, 7.61)
9:133799156	rs373084105	M>T	B:275	(55.11, 32.50, 7.61)
9:133799153		R>H	B:276	(55.02, 26.50, 8.30)
9:133799154	rs369690143	R>C	B:276	(55.02, 26.50, 8.30)
9:133799150		T>M	B:277	(49.31, 28.71, 10.18)
9:133799145		G>S	B:279	(49.34, 30.35, 4.93)
9:133799141		G>D	B:280	(50.26, 32.57, 6.84)
9:133799139		G>S	B:281	(50.98, 35.69, 8.55)
9:133799132	rs151264671	T>M	B:283	(51.86, 38.38, 14.39)
9:133787263		R>W	B:288	(53.78, 29.58, 28.02)
9:133787260	rs568093970	E>K	B:289	(58.08, 26.46, 24.61)
9:133787256		D>G	B:290	(59.90, 25.70, 28.42)
9:133787257	rs142317287	D>N	B:290	(59.90, 25.70, 28.42)
9:133787254	rs369193753	G>S	B:291	(59.01, 27.36, 31.69)
9:133787248	rs147669758	V>M	B:293	(59.73, 32.56, 31.17)
9:133787237	rs145385892	F>L	B:296	(52.97, 36.05, 38.95)
9:133787235	rs199643737 COSM1739569	R>Q	B:297	(56.32, 39.90, 35.36)
9:133787223		A>V	B:301	(55.50, 43.76, 32.02)
9:133787224	rs550474087	A>T	B:301	(55.50, 43.76, 32.02)
9:133787218	rs144181457	R>G	B:303	(53.29, 48.66, 29.85)
9:133787212		G>S	B:305	(57.17, 43.02, 27.81)
9:133787207		F>L	B:306	(57.38, 39.12, 29.31)
9:133787206		G>S	B:307	(61.25, 37.76, 26.84)
9:133787202		R>K	B:308	(64.85, 35.77, 25.25)
9:133787191		E>K	B:312	(58.64, 31.09, 26.90)
9:133787187		H>P	B:313	(57.06, 35.66, 23.67)
9:133787188		H>Y	B:313	(57.06, 35.66, 23.67)
9:133787179		G>R	B:316	(52.85, 43.59, 24.59)
9:133780783	rs139158805	A>T	B:322	(49.40, 48.88, 17.63)
9:133780773		T>I	B:325	(44.35, 49.59, 16.16)
9:133780771		Q>E	B:326	(47.10, 48.61, 11.93)
9:133780767		A>V	B:327	(43.34, 46.61, 11.37)
9:133780759		E>K	B:330	(42.13, 36.53, 12.31)
9:133780753		H>N	B:332	(45.30, 30.68, 15.57)
9:133780750		V>M	B:333	(44.99, 29.79, 19.85)
9:133780746		D>V	B:334	(48.17, 27.06, 18.35)
9:133780741		E>K	B:336	(50.95, 20.66, 22.40)
9:133780736		D>E	B:337	(49.02, 17.78, 25.11)
9:133780725		G>A	B:341	(48.27, 16.91, 21.46)
9:133780722	rs376241321	T>M	B:342	(47.03, 19.18, 18.85)
9:133780710	rs201660431	R>H	B:346	(40.87, 30.97, 13.75)
9:133780711	rs563360482	R>C	B:346	(40.87, 30.97, 13.75)
9:133780705		G>R	B:348	(37.50, 36.87, 13.67)
9:133780696	rs377608283	G>S	B:351	(41.41, 43.26, 20.36)
9:133780693	rs145939538	V>M	B:352	(43.63, 45.37, 22.59)
9:133780689		G>D	B:353	(41.75, 49.03, 22.96)
9:133780682		F>L	B:355	(37.33, 52.16, 19.40)
9:133780669		E>Q	B:360	(48.01, 52.10, 30.26)
9:133780660	rs374267794	G>R	B:363	(43.02, 48.14, 30.27)
9:133780656		Y>S	B:364	(45.87, 47.82, 27.30)
9:133780653		P>L	B:365	(40.11, 46.72, 26.62)
9:133780645	rs555984144 COSM3904816	V>M	B:368	(36.66, 38.44, 21.26)
9:133780630		G>S	B:373	(37.37, 24.87, 16.37)
9:133779704		S>F	B:378	(37.96, 29.44, 26.46)
9:133779687	rs201510681 COSM3329358	G>S	B:384	(35.23, 43.43, 27.81)
9:133779672	rs148162298	T>A	B:389	(47.85, 42.35, 36.94)
9:133779657		S>G	B:394	(40.22, 45.39, 36.52)
9:133779635		C>Y	B:401	(41.93, 36.81, 39.42)
9:133779620		R>H	B:406	(49.24, 32.49, 41.29)
9:133779621		R>C	B:406	(49.24, 32.49, 41.29)
9:133779618		G>S	B:407	(48.45, 35.52, 36.37)
9:133779610		W>C	B:409	(44.01, 36.08, 30.15)
9:133779602	rs573589654 COSM3654928	R>H	B:412	(33.68, 38.31, 33.84)
9:133779603		R>C	B:412	(33.68, 38.31, 33.84)
9:133779590		T>M	B:416	(37.54, 30.03, 30.68)
9:133779569		Y>C	B:423	(54.95, 25.12, 32.05)
9:133779563	rs138892175	R>H	B:425	(56.12, 20.44, 34.05)
9:133779557	rs12342367	A>V	B:427	(48.36, 17.23, 35.90)
9:133779558		A>T	B:427	(48.36, 17.23, 35.90)
9:133779552	rs143570837	A>T	B:429	(45.82, 19.62, 42.26)
9:133779540	rs147030133	D>N	B:433	(46.95, 27.43, 38.99)
9:133779536		G>D	B:434	(47.68, 27.19, 34.90)
9:133779530	rs116149234	E>G	B:436	(44.57, 26.07, 32.32)
9:133779525	rs372947957	S>P	B:438	(38.66, 24.86, 29.97)
9:133779489		S>P	B:450	(50.96, 28.33, 23.91)
9:133779476		I>N	B:454	(47.54, 38.53, 15.00)
9:133779473		R>Q	B:455	(45.88, 36.18, 9.36)
9:133779474	rs369324500	R>W	B:455	(45.88, 36.18, 9.36)

4M7H.B | FIBCD1.

4M7H.B | FIBCD1

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:133787218	COSM3718725	R>G	B:303	(53.29, 48.66, 29.85)
9:133779637	COSM1624636	N>K	B:400	(43.50, 39.60, 42.07)
9:133779602	COSM3654928	R>H	B:412	(33.68, 38.31, 33.84)
9:133779548	COSM3733698	S>C	B:430	(45.91, 23.02, 41.58)