General Structure Information
| PDB ID | 2y1x |
| HGNC Gene Label(s) | CARM1 |
| Structure Name | crystal structure of coactivator associated arginine methyltransferase 1 (carm1) in complex with sinefungin and indole inhibitor |
| Resolution | 2.4Å |
| Reference | AUTH J.S.SACK,S.THIEFFINE,T.BANDIERA,M.FASOLINI,G.J.DUKE,AUTH 2 L.JAYARAMAN,K.F.KISH,H.E.KLEI,A.V.PURANDARE,P.ROSETTANI,AUTH 3 S.TROIANI,D.XIE,J.A.BERTRANDTITL STRUCTURAL BASIS FOR CARM1 INHIBITION BY INDOLE ANDTITL 2 PYRAZOLE INHIBITORSREF BIOCHEM.J. V. 436 331 2011REFN ISSN 0264-6021PMID 21410432DOI 10.1042/BJ20102161 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 343 |
| Number Of SNVs | 26 |
| Number Of Permutations | 6357 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.037 |
| p-value | 0.043 |
COSMIC
| Number Of Residues | 343 |
| Number Of SNVs | 3 |
| Number Of Permutations | 109 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.667 |
| p-value | 0.293 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 26 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.431 |
| p-value | 0.636 |