General Structure Information
| PDB ID | 4lev |
| HGNC Gene Label(s) | MB21D1 |
| Structure Name | structure of human cgas |
| Resolution | 1.95Å |
| Reference | AUTH X.LI,C.SHU,G.YI,C.T.CHATON,C.L.SHELTON,J.DIAO,X.ZUO,C.C.KAO,AUTH 2 A.B.HERR,P.LITITL CYCLIC GMP-AMP SYNTHASE IS ACTIVATED BY DOUBLE-STRANDEDTITL 2 DNA-INDUCED OLIGOMERIZATION.REF IMMUNITY V. 39 1019 2013REFN ISSN 1074-7613PMID 24332030DOI 10.1016/J.IMMUNI.2013.10.019 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 361 |
| Number Of SNVs | 83 |
| Number Of Permutations | 37625 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.147 |
| p-value | 0.61 |
COSMIC
| Number Of Residues | 361 |
| Number Of SNVs | 9 |
| Number Of Permutations | 1880 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.25 |
| p-value | 0.163 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 83 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.107 |
| p-value | 0.896 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
