General Structure Information
| PDB ID | 4mwi |
| HGNC Gene Label(s) | MLKL |
| Structure Name | crystal structure of the human mlkl pseudokinase domain |
| Resolution | 1.7Å |
| Reference | AUTH J.M.MURPHY,I.S.LUCET,J.M.HILDEBRAND,M.C.TANZER,S.N.YOUNG,AUTH 2 P.SHARMA,G.LESSENE,W.S.ALEXANDER,J.J.BABON,J.SILKE,AUTH 3 P.E.CZABOTARTITL INSIGHTS INTO THE EVOLUTION OF DIVERGENT NUCLEOTIDE-BINDINGTITL 2 MECHANISMS AMONG PSEUDOKINASES REVEALED BY CRYSTALTITL 3 STRUCTURES OF HUMAN AND MOUSE MLKL.REF BIOCHEM.J. V. 457 369 2014REFN ISSN 0264-6021PMID 24219132DOI 10.1042/BJ20131270 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 266 |
| Number Of SNVs | 100 |
| Number Of Permutations | 44274 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.024 |
| p-value | 0.63 |
COSMIC
| Number Of Residues | 266 |
| Number Of SNVs | 6 |
| Number Of Permutations | 121 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.067 |
| p-value | 0.978 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 100 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.557 |
| p-value | 0.044 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
