General Structure Information
| PDB ID | 4ekg |
| HGNC Gene Label(s) | DOT1L |
| Structure Name | crystal structure of dot1l in complex with epz003696 |
| Resolution | 2.8Å |
| Reference | AUTH A.BASAVAPATHRUNI,L.JIN,S.R.DAIGLE,C.R.MAJER,C.A.THERKELSEN,AUTH 2 T.J.WIGLE,K.W.KUNTZ,R.CHESWORTH,R.M.POLLOCK,M.P.SCOTT,AUTH 3 M.P.MOYER,V.M.RICHON,R.A.COPELAND,E.J.OLHAVATITL CONFORMATIONAL ADAPTATION DRIVES POTENT, SELECTIVE ANDTITL 2 DURABLE INHIBITION OF THE HUMAN PROTEIN METHYLTRANSFERASETITL 3 DOT1L.REF CHEM.BIOL.DRUG DES. V. 80 971 2012REFN ISSN 1747-0277PMID 22978415DOI 10.1111/CBDD.12050 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 319 |
| Number Of SNVs | 20 |
| Number Of Permutations | 18481 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.032 |
| p-value | 0.849 |
COSMIC
| Number Of Residues | 319 |
| Number Of SNVs | 3 |
| Number Of Permutations | 140 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.667 |
| p-value | 0.805 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 20 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | -0.453 |
| p-value | 0.699 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
