General Structure Information
| PDB ID | 4k6j |
| HGNC Gene Label(s) | WAPAL |
| Structure Name | human cohesin inhibitor wapl |
| Resolution | 2.62Å |
| Reference | AUTH Z.OUYANG,G.ZHENG,J.SONG,D.M.BOREK,Z.OTWINOWSKI,AUTH 2 C.A.BRAUTIGAM,D.R.TOMCHICK,S.RANKIN,H.YUTITL STRUCTURE OF THE HUMAN COHESIN INHIBITOR WAPL.REF PROC.NATL.ACAD.SCI.USA V. 110 11355 2013REFN ISSN 0027-8424PMID 23776203DOI 10.1073/PNAS.1304594110 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 489 |
| Number Of SNVs | 44 |
| Number Of Permutations | 35641 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.48 |
| p-value | 0.005 |
COSMIC
| Number Of Residues | 489 |
| Number Of SNVs | 4 |
| Number Of Permutations | 596 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.167 |
| p-value | 0.498 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 44 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | -0.535 |
| p-value | 0.262 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
