General Structure Information
| PDB ID | 3um1 |
| HGNC Gene Label(s) | BROX |
| Structure Name | crystal structure of the brox bro1 domain in complex with the c- terminal tail of chmp5 |
| Resolution | 2.71Å |
| Reference | AUTH R.MU,V.DUSSUPT,J.JIANG,P.SETTE,V.RUDD,W.CHUENCHOR,N.F.BELLO,AUTH 2 F.BOUAMR,T.S.XIAOTITL TWO DISTINCT BINDING MODES DEFINE THE INTERACTION OF BROXTITL 2 WITH THE C-TERMINAL TAILS OF CHMP5 AND CHMP4B.REF STRUCTURE V. 20 887 2012REFN ISSN 0969-2126PMID 22484091DOI 10.1016/J.STR.2012.03.001 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 375 |
| Number Of SNVs | 91 |
| Number Of Permutations | 30910 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.011 |
| p-value | 0.955 |
COSMIC
| Number Of Residues | 375 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1824 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.1 |
| p-value | 0.67 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 91 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | -0.133 |
| p-value | 0.866 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
