General Structure Information
| PDB ID | 4nm6 |
| HGNC Gene Label(s) | TET2 |
| Structure Name | crystal structure of tet2-dna complex |
| Resolution | 2.03Å |
| Reference | AUTH L.HU,Z.LI,J.CHENG,Q.RAO,W.GONG,M.LIU,Y.G.SHI,J.ZHU,P.WANG,AUTH 2 Y.XUTITL CRYSTAL STRUCTURE OF TET2-DNA COMPLEX: INSIGHT INTOTITL 2 TET-MEDIATED 5MC OXIDATION.REF CELL(CAMBRIDGE,MASS.) V. 155 1545 2013REFN ISSN 0092-8674PMID 24315485DOI 10.1016/J.CELL.2013.11.020 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 407 |
| Number Of SNVs | 33 |
| Number Of Permutations | 21644 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.036 |
| p-value | 0.293 |
COSMIC
| Number Of Residues | 407 |
| Number Of SNVs | 39 |
| Number Of Permutations | 31944 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.128 |
| p-value | 0.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 33 |
| Number Of COSMIC SNVs | 30 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.094 |
| p-value | 0.111 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
