General Structure Information
| PDB ID | 3iec |
| HGNC Gene Label(s) | MARK2 |
| Structure Name | helicobacter pylori caga inhibits par1/mark family kinases by mimicking host substrates |
| Resolution | 2.2Å |
| Reference | AUTH D.NESIC,M.C.MILLER,Z.T.QUINKERT,M.STEIN,B.T.CHAIT,AUTH 2 C.E.STEBBINSTITL HELICOBACTER PYLORI CAGA INHIBITS PAR1-MARK FAMILY KINASESTITL 2 BY MIMICKING HOST SUBSTRATES.REF NAT.STRUCT.MOL.BIOL. V. 17 130 2010REFN ISSN 1545-9993PMID 19966800DOI 10.1038/NSMB.1705 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 313 |
| Number Of SNVs | 27 |
| Number Of Permutations | 15670 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.04 |
| p-value | 0.038 |
COSMIC
| Number Of Residues | 313 |
| Number Of SNVs | 10 |
| Number Of Permutations | 3873 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.2 |
| p-value | 0.028 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 27 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | -0.222 |
| p-value | 0.189 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
