General Structure Information
| PDB ID | 3bpt |
| HGNC Gene Label(s) | HIBCH |
| Structure Name | crystal structure of human beta-hydroxyisobutyryl-coa hydrolase in complex with quercetin |
| Resolution | 1.5Å |
| Reference | AUTH E.S.PILKA,C.PHILLIPS,O.N.F.KING,K.GUO,F.VON DELFT,AUTH 2 A.C.W.PIKE,C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA-HYDROXYISOBUTYRYL-COATITL 2 HYDROLASE IN COMPLEX WITH QUERCETIN.REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 345 |
| Number Of SNVs | 86 |
| Number Of Permutations | 15727 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.015 |
| p-value | 0.702 |
ClinVar
| Number Of Residues | 345 |
| Number Of SNVs | 4 |
| Number Of Permutations | 420 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.333 |
| p-value | 0.716 |
COSMIC
| Number Of Residues | 345 |
| Number Of SNVs | 3 |
| Number Of Permutations | 139 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.333 |
| p-value | 0.861 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 86 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.17 |
| p-value | 0.802 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 86 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.205 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
