General Structure Information
| PDB ID | 4mi0 |
| HGNC Gene Label(s) | EZH2 |
| Structure Name | human enhancer of zeste (drosophila) homolog 2(ezh2) |
| Resolution | 2.0Å |
| Reference | AUTH H.WU,H.ZENG,A.DONG,F.LI,H.HE,G.SENISTERRA,A.SEITOVA,S.DUAN,AUTH 2 P.J.BROWN,M.VEDADI,C.H.ARROWSMITH,M.SCHAPIRATITL STRUCTURE OF THE CATALYTIC DOMAIN OF EZH2 REVEALSTITL 2 CONFORMATIONAL PLASTICITY IN COFACTOR AND SUBSTRATE BINDINGTITL 3 SITES AND EXPLAINS ONCOGENIC MUTATIONS.REF PLOS ONE V. 8 83737 2013REFN ESSN 1932-6203PMID 24367611DOI 10.1371/JOURNAL.PONE.0083737 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 208 |
| Number Of SNVs | 12 |
| Number Of Permutations | 5674 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.061 |
| p-value | 0.605 |
ClinVar
| Number Of Residues | 208 |
| Number Of SNVs | 4 |
| Number Of Permutations | 846 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.333 |
| p-value | 0.247 |
COSMIC
| Number Of Residues | 208 |
| Number Of SNVs | 17 |
| Number Of Permutations | 17931 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.206 |
| p-value | 0.366 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 12 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.197 |
| p-value | 0.203 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 12 |
| Number Of COSMIC SNVs | 14 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | -0.062 |
| p-value | 0.678 |