General Structure Information
| PDB ID | 3qbv |
| HGNC Gene Label(s) | ITSN1 |
| Structure Name | structure of designed orthogonal interaction between cdc42 and nucleotide exchange domains of intersectin |
| Resolution | 2.65Å |
| Reference | AUTH G.T.KAPP,S.LIU,A.STEIN,D.T.WONG,A.REMENYI,B.J.YEH,AUTH 2 J.S.FRASER,J.TAUNTON,W.A.LIM,T.KORTEMMETITL CONTROL OF PROTEIN SIGNALING USING A COMPUTATIONALLYTITL 2 DESIGNED GTPASE/GEF ORTHOGONAL PAIR.REF PROC.NATL.ACAD.SCI.USA V. 109 5277 2012REFN ISSN 0027-8424PMID 22403064DOI 10.1073/PNAS.1114487109 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 307 |
| Number Of SNVs | 50 |
| Number Of Permutations | 36663 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.042 |
| p-value | 0.817 |
COSMIC
| Number Of Residues | 307 |
| Number Of SNVs | 3 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
