General Structure Information
| PDB ID | 3hkv |
| HGNC Gene Label(s) | PARP10 |
| Structure Name | human poly(adp-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide |
| Resolution | 2.1Å |
| Reference | AUTH T.KARLBERG,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,A.KOTZSCH,T.K.NIELSEN,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.K.ROOS,J.SAGEMARK,P.SCHUTZ,AUTH 6 M.I.SIPONEN,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 8 H.SCHULERTITL HUMAN POLY(ADP-RIBOSE) POLYMERASE 10, CATALYTICTITL 2 FRAGMENT IN COMPLEX WITH AN INHIBITORTITL 3 3-AMINOBENZAMIDEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 192 |
| Number Of SNVs | 53 |
| Number Of Permutations | 7909 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.274 |
| p-value | 0.105 |
COSMIC
| Number Of Residues | 192 |
| Number Of SNVs | 4 |
| Number Of Permutations | 334 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.167 |
| p-value | 0.699 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.274 |
| p-value | 0.579 |