2HZP.A | KYNU – ASTRID

2HZP.A | KYNU

General Structure Information

PDB ID	2hzp
HGNC Gene Label(s)	KYNU
Structure Name	crystal structure of homo sapiens kynureninase
Resolution	2.0Å
Reference	AUTH S.LIMA,R.KHRISTOFOROV,C.MOMANY,R.S.PHILLIPSTITL CRYSTAL STRUCTURE OF HOMO SAPIENS KYNURENINASE.REF BIOCHEMISTRY V. 46 2735 2007REFN ISSN 0006-2960PMID 17300176DOI 10.1021/BI0616697

Variant Set Distributions

ExAC Variants

Number Of Residues	446
Number Of SNVs	138
Number Of Permutations	27540
Optimal Distance Threshold	6.0
K Statistic	0.008
p-value	0.185

COSMIC

Number Of Residues	446
Number Of SNVs	10
Number Of Permutations	10195
Optimal Distance Threshold	24.0
K Statistic	0.222
p-value	0.355

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	138
Number Of COSMIC SNVs	9
Optimal Distance Threshold	13.0
K Statistic	-0.079
p-value	0.171

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:143642959		L>P	A:8	(62.59, 41.85, 33.53)
2:143642961		P>S	A:9	(59.60, 44.64, 32.52)
2:143642962	rs376052980	P>L	A:9	(59.60, 44.64, 32.52)
2:143642967		D>N	A:11	(63.34, 45.51, 36.99)
2:143642980	rs200861229	R>H	A:15	(66.01, 51.83, 35.59)
2:143642994		L>F	A:20	(61.88, 60.17, 37.53)
2:143643000		C>R	A:22	(59.09, 58.41, 41.58)
2:143643006	rs141597680	P>S	A:24	(56.96, 52.88, 40.74)
2:143643019	COSM325652 COSM325653	R>K	A:28	(56.85, 61.77, 37.16)
2:143643021		V>M	A:29	(56.75, 56.34, 35.01)
2:143643055		R>K	A:40	(54.04, 58.70, 21.40)
2:143643057	rs146238174	H>Y	A:41	(55.94, 58.17, 15.29)
2:143643060		F>L	A:42	(54.16, 54.84, 14.22)
2:143643063		R>G	A:43	(49.14, 58.01, 19.24)
2:143643072		F>L	A:46	(46.57, 54.29, 13.63)
2:143643078		I>F	A:48	(42.10, 57.07, 18.34)
2:143643084		K>E	A:50	(37.20, 60.76, 20.93)
2:143643094		D>V	A:53	(31.65, 58.90, 20.02)
2:143643095		D>E	A:53	(31.65, 58.90, 20.02)
2:143643100		P>L	A:55	(28.11, 53.09, 22.28)
2:143676180		D>N	A:58	(27.93, 57.25, 31.62)
2:143676197	rs201592797	N>K	A:63	(36.43, 63.75, 30.80)
2:143676201		D>N	A:65	(36.94, 65.82, 23.69)
2:143676213		I>V	A:69	(41.26, 53.40, 27.02)
2:143676244		Q>P	A:79	(41.13, 53.38, 10.21)
2:143676247		P>R	A:80	(44.84, 52.86, 9.04)
2:143676267		L>V	A:87	(40.42, 52.71, -1.09)
2:143676273	COSM4085240 COSM4085241	E>K	A:89	(45.35, 55.33, -5.12)
2:143676276	COSM1399775 COSM1399776	E>Q	A:90	(42.79, 51.45, -6.94)
2:143676282		D>H	A:92	(40.58, 57.46, -8.88)
2:143676287		K>N	A:93	(42.88, 52.52, -11.68)
2:143685229		A>T	A:98	(38.64, 50.47, -16.02)
2:143685236		Y>C	A:100	(42.42, 49.27, -20.22)
2:143685251	COSM1186017 COSM1186018	G>A	A:105	(49.91, 50.31, -11.80)
2:143685256	rs373416306	R>C	A:107	(47.74, 49.14, -5.88)
2:143685257	rs545230086	R>H	A:107	(47.74, 49.14, -5.88)
2:143685263	COSM3567293 COSM3567294	W>S	A:109	(42.53, 46.11, -10.73)
2:143685271	rs375973950	G>R	A:112	(47.54, 42.79, -5.96)
2:143685274		D>N	A:113	(48.11, 39.53, -4.39)
2:143685281	rs142820434	S>N	A:115	(51.78, 44.17, -4.91)
2:143685284	rs369102028	I>T	A:116	(51.07, 43.87, -0.89)
2:143685305		I>T	A:123	(55.17, 40.29, 9.56)
2:143712381	COSM245379 COSM3894895	A>T	A:126	(58.65, 34.30, 4.82)
2:143712382		A>V	A:126	(58.65, 34.30, 4.82)
2:143712388		E>A	A:128	(57.58, 37.18, -1.97)
2:143712396		I>V	A:131	(53.33, 34.49, 1.58)
2:143712399		A>S	A:132	(49.15, 34.04, 0.39)
2:143712430		H>R	A:142	(38.63, 24.28, 5.49)
2:143713775		S>P	A:147	(46.17, 19.19, 1.05)
2:143713787		P>T	A:151	(43.51, 10.35, 6.51)
2:143713791	rs146601376	T>M	A:152	(45.77, 6.60, 7.41)
2:143713794		P>Q	A:153	(44.27, 3.46, 8.90)
2:143713800	COSM377055 COSM377056	R>Q	A:155	(49.77, 9.04, 10.93)
2:143713815		L>P	A:160	(43.27, 20.59, 18.85)
2:143713817		E>K	A:161	(43.77, 24.12, 21.29)
2:143713826		A>S	A:164	(39.40, 26.34, 20.39)
2:143713833	COSM139403 COSM3406915 COSM3406916	P>R	A:166	(34.96, 28.60, 17.48)
2:143713836		S>C	A:167	(36.05, 28.43, 13.34)
2:143715214	rs147928469	A>V	A:171	(36.94, 23.02, 10.66)
2:143715220	rs201791037	E>G	A:173	(34.08, 18.94, 13.95)
2:143715221		E>D	A:173	(34.08, 18.94, 13.95)
2:143715240	rs373422189	G>R	A:180	(34.46, 9.41, 8.26)
2:143715250	rs375813192	I>T	A:183	(34.75, 13.42, 15.93)
2:143715259	rs369993662	S>N	A:186	(39.85, 11.59, 15.57)
2:143715264	rs147103103	R>W	A:188	(43.78, 14.55, 21.89)
2:143715276		P>A	A:192	(43.89, 22.00, 31.05)
2:143715282	rs375714486	E>K	A:194	(42.47, 19.75, 38.63)
2:143718194		G>E	A:195	(43.25, 24.41, 38.10)
2:143718202		T>A	A:198	(47.20, 27.47, 30.89)
2:143718212		I>T	A:201	(55.38, 22.81, 26.74)
2:143718226		E>K	A:206	(53.57, 13.62, 27.68)
2:143718236		E>G	A:209	(56.57, 10.96, 22.31)
2:143718247	rs373954314	D>N	A:213	(52.97, 7.53, 15.66)
2:143718254		I>T	A:215	(48.80, 12.61, 15.14)
2:143718260		V>A	A:217	(47.55, 17.33, 11.52)
2:143718284		F>S	A:225	(40.46, 32.84, 22.22)
2:143718310		P>S	A:234	(59.37, 26.29, 17.53)
2:143718326	rs199529102	A>V	A:239	(57.69, 17.40, 18.14)
2:143718331	rs372047239	Q>K	A:241	(58.08, 17.79, 12.18)
2:143718337		K>E	A:243	(56.40, 11.14, 16.30)
2:143742658	rs137982021	C>W	A:245	(53.42, 15.04, 12.33)
2:143742659		Y>H	A:246	(52.18, 16.99, 7.74)
2:143742660		Y>C	A:246	(52.18, 16.99, 7.74)
2:143742666		G>V	A:248	(50.07, 23.97, 12.09)
2:143742681	rs372144733	H>R	A:253	(44.97, 36.40, 18.29)
2:143742686		V>L	A:255	(50.21, 37.99, 12.81)
2:143742694		N>K	A:257	(51.53, 40.17, 18.67)
2:143742695		V>F	A:258	(54.32, 37.62, 18.15)
2:143742696	rs376794557	V>A	A:258	(54.32, 37.62, 18.15)
2:143742705	rs369069974	Y>C	A:261	(61.45, 34.21, 12.89)
2:143742710		H>Y	A:263	(61.69, 29.16, 6.09)
2:143742717	COSM1528343 COSM1528344	W>S	A:265	(60.13, 29.12, 13.98)
2:143742723		V>A	A:267	(56.14, 25.75, 10.02)
2:143742731		A>P	A:270	(49.72, 28.81, 8.09)
2:143743530		G>V	A:281	(39.38, 45.36, 8.42)
2:143743533	rs149755270	A>V	A:282	(36.27, 43.91, 8.70)
2:143743536		G>E	A:283	(37.09, 40.93, 6.59)
2:143743553		F>L	A:289	(53.50, 29.36, 5.49)
2:143743556		I>L	A:290	(52.84, 26.55, 2.31)
2:143743559		H>D	A:291	(58.39, 25.52, 4.19)
2:143743563	rs576933121	E>G	A:292	(60.41, 26.50, 0.21)
2:143743578	rs544190058	T>M	A:297	(55.05, 17.49, -2.51)
2:143787216		H>L	A:308	(47.53, 29.01, -14.87)
2:143787224	rs200565083	S>G	A:311	(52.45, 33.59, -18.38)
2:143787243		D>G	A:317	(44.44, 26.82, -22.87)
2:143790816	rs539737850	I>F	A:323	(51.67, 28.33, -9.19)
2:143790822		G>R	A:325	(52.80, 26.32, -3.79)
2:143790844		S>L	A:332	(40.13, 33.59, -7.20)
2:143790849	rs374687401	P>S	A:334	(42.51, 39.47, -6.35)
2:143790850	rs367959783 COSM3567320	P>R	A:334	(42.51, 39.47, -6.35)
2:143790860	rs374836063	L>F	A:337	(38.71, 47.47, -2.35)
2:143790870		S>A	A:341	(43.24, 48.09, 3.61)
2:143790877		H>R	A:343	(49.57, 48.69, 0.98)
2:143790884		S>R	A:345	(48.85, 48.44, 7.64)
2:143790886	rs372960169	L>S	A:346	(51.51, 46.12, 5.73)
2:143798010		A>E	A:352	(58.04, 49.89, 12.83)
2:143798019	rs537147146	K>T	A:355	(63.17, 44.22, 16.81)
2:143798022	rs555569996	A>E	A:356	(60.19, 47.40, 17.83)
2:143798027	rs140239671	R>W	A:358	(57.49, 41.34, 21.56)
2:143798028	rs377612575 COSM3425251	R>Q	A:358	(57.49, 41.34, 21.56)
2:143798055	rs573910765	Y>C	A:367	(53.39, 50.05, 33.29)
2:143798069		I>V	A:372	(47.47, 44.71, 37.91)
2:143798073		K>R	A:373	(50.68, 41.65, 40.18)
2:143798088		K>T	A:378	(44.63, 38.31, 47.30)
2:143798123		I>V	A:390	(47.07, 37.64, 35.52)
2:143798132	rs371441647 COSM334383	P>S	A:393	(51.25, 33.38, 30.74)
2:143798133	rs376044073	P>L	A:393	(51.25, 33.38, 30.74)
2:143798141		V>L	A:396	(58.04, 37.73, 28.74)
2:143798151	COSM1212923	R>Q	A:399	(53.19, 37.58, 27.97)
2:143798157		C>Y	A:401	(49.71, 42.28, 23.82)
2:143798163	COSM3728145	L>P	A:403	(46.82, 40.43, 29.80)
2:143798166		T>I	A:404	(43.30, 37.10, 30.48)
2:143798189	rs9013	K>E	A:412	(31.19, 45.73, 41.01)
2:143798195		V>I	A:414	(34.67, 44.87, 36.10)
2:143798196	COSM1007107	V>G	A:414	(34.67, 44.87, 36.10)
2:143798217		R>K	A:421	(33.89, 54.39, 33.77)
2:143798223		V>A	A:423	(37.61, 50.80, 28.65)
2:143799623		K>R	A:427	(33.32, 39.70, 29.42)
2:143799625	rs147475752	R>W	A:428	(37.08, 35.09, 31.25)
2:143799626	rs575964691	R>Q	A:428	(37.08, 35.09, 31.25)
2:143799638		G>D	A:432	(36.27, 39.42, 33.11)
2:143799644		R>Q	A:434	(39.86, 38.48, 27.40)
2:143799647	rs199546957	V>A	A:435	(43.27, 43.63, 28.08)
2:143799671		S>Y	A:443	(50.08, 54.54, 25.69)
2:143799682		V>I	A:447	(48.32, 51.33, 30.97)
2:143799698		N>S	A:452	(43.84, 54.68, 38.12)
2:143799701		L>R	A:453	(39.52, 53.58, 35.70)
2:143799710		S>F	A:456	(38.02, 53.04, 41.30)
2:143799712		I>V	A:457	(35.91, 49.80, 39.56)
2:143799713		I>T	A:457	(35.91, 49.80, 39.56)
2:143799715		L>I	A:458	(38.20, 46.87, 42.35)

2HZP.A | KYNU.

2HZP.A | KYNU

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:143643019	COSM325652	R>K	A:28	(56.85, 61.77, 37.16)
2:143643073	COSM1613448	F>Y	A:46	(46.57, 54.29, 13.63)
2:143676226	COSM3567292	G>E	A:73	(43.38, 45.20, 18.81)
2:143676232	COSM3425247	S>Y	A:75	(39.52, 41.92, 17.68)
2:143685266	COSM1007097	I>N	A:110	(45.77, 40.50, -12.40)
2:143712381	COSM245379	A>T	A:126	(58.65, 34.30, 4.82)
2:143713800	COSM377055	R>Q	A:155	(49.77, 9.04, 10.93)
2:143787241	COSM716523	M>I	A:316	(41.62, 31.67, -21.51)
2:143798027	COSM282334	R>W	A:358	(57.49, 41.34, 21.56)
2:143798189	COSM3757655	K>E	A:412	(31.19, 45.73, 41.01)