General Structure Information
| PDB ID | 4at4 |
| HGNC Gene Label(s) | NTRK2 |
| Structure Name | crystal structure of trkb kinase domain in complex with ex429 |
| Resolution | 2.36Å |
| Reference | AUTH T.BERTRAND,M.KOTHE,J.LIU,A.DUPUY,A.RAK,P.F.BERNE,S.DAVIS,AUTH 2 T.GLADYSHEVA,C.VALTRE,J.Y.CRENNE,M.MATHIEUTITL THE CRYSTAL STRUCTURES OF TRKA AND TRKB SUGGEST KEY REGIONSTITL 2 FOR ACHIEVING SELECTIVE INHIBITION.REF J.MOL.BIOL. V. 423 439 2012REFN ISSN 0022-2836PMID 22902478DOI 10.1016/J.JMB.2012.08.002 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 289 |
| Number Of SNVs | 29 |
| Number Of Permutations | 3790 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.106 |
| p-value | 0.019 |
COSMIC
| Number Of Residues | 289 |
| Number Of SNVs | 8 |
| Number Of Permutations | 3386 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.036 |
| p-value | 0.028 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 29 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.51 |
| p-value | 0.022 |