3VPP.A | CLEC9A

PDB ID	3vpp
HGNC Gene Label(s)	CLEC9A
Structure Name	crystal structure of the human clec9a c-type lectin-like domain
Resolution	1.64Å
Reference	AUTH J.G.ZHANG,P.E.CZABOTAR,A.N.POLICHENI,I.CAMINSCHI,S.S.WAN,AUTH 2 S.KITSOULIS,K.M.TULLETT,A.Y.ROBIN,R.BRAMMANANTH,AUTH 3 M.F.VAN DELFT,J.LU,L.A.OREILLY,E.C.JOSEFSSON,B.T.KILE,AUTH 4 W.J.CHIN,J.D.MINTERN,M.A.OLSHINA,W.WONG,J.BAUM,M.D.WRIGHT,AUTH 5 D.C.HUANG,N.MOHANDAS,R.L.COPPEL,P.M.COLMAN,N.A.NICOLA,AUTH 6 K.SHORTMAN,M.H.LAHOUDTITL THE DENDRITIC CELL RECEPTOR CLEC9A BINDS DAMAGED CELLS VIATITL 2 EXPOSED ACTIN FILAMENTS.REF IMMUNITY V. 36 646 2012REFN ISSN 1074-7613PMID 22483802DOI 10.1016/J.IMMUNI.2012.03.009

ExAC Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
12:10215699		E>G	A:122	(-15.23, -2.97, -1.90)
12:10215713	rs146186714	V>F	A:127	(-8.19, 11.81, 6.43)
12:10215719		E>K	A:129	(-5.95, 15.49, 11.72)
12:10215729	rs139004061	S>N	A:132	(4.23, 12.50, 7.54)
12:10215771		S>F	A:146	(-3.62, 0.21, 6.28)
12:10215795		K>T	A:154	(-13.51, 8.92, -12.64)
12:10215797	rs144816992	E>Q	A:155	(-16.09, 5.48, -8.74)
12:10215804		M>K	A:157	(-10.17, 10.74, -7.82)
12:10217331	rs148583174	D>H	A:158	(-14.69, 11.50, -8.41)
12:10217375	COSM1238529	D>E	A:172	(-0.85, 18.57, 0.51)
12:10217379		W>R	A:174	(2.51, 12.11, 0.87)
12:10217382		V>L	A:175	(-0.96, 8.85, -2.31)
12:10217391		S>P	A:178	(6.14, 5.59, -6.33)
12:10217395		Q>R	A:179	(8.81, 8.38, -9.89)
12:10217403		H>Y	A:182	(16.69, 3.72, -12.43)
12:10217409		G>R	A:184	(9.76, 7.34, -14.12)
12:10217412	rs147713876	R>C	A:185	(6.86, 3.40, -14.90)
12:10217413	rs142470425	R>H	A:185	(6.86, 3.40, -14.90)
12:10217427		D>Y	A:190	(-0.03, -2.98, -5.78)
12:10218109	rs201379734	E>Q	A:202	(5.49, 17.11, -15.09)
12:10218145	rs368520956	V>M	A:214	(-4.01, 14.46, -3.54)
12:10218154		N>H	A:217	(-9.45, 18.30, -7.94)
12:10218167	COSM279935	S>L	A:221	(5.09, 15.43, -7.56)
12:10218179		S>T	A:225	(12.08, 13.96, 2.93)
12:10218182		T>M	A:226	(8.21, 16.09, 2.31)
12:10218195		F>L	A:230	(-1.55, 10.35, 6.27)
12:10218196		I>L	A:231	(-5.27, 9.32, 2.62)
12:10218202		E>K	A:233	(-7.43, 2.17, 1.21)
12:10218207		K>N	A:234	(-8.85, -0.67, 5.74)

3VPP.A | CLEC9A.