General Structure Information
| PDB ID | 3blj |
| HGNC Gene Label(s) | PARP15 |
| Structure Name | crystal structure of human poly(adp-ribose) polymerase 15, catalytic fragment |
| Resolution | 2.2Å |
| Reference | AUTH T.KARLBERG,M.KLEPSCH,A.G.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASE ACTIVITYTITL 2 IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGER ANTIVIRALTITL 3 PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 192 |
| Number Of SNVs | 57 |
| Number Of Permutations | 25408 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.026 |
| p-value | 0.395 |
COSMIC
| Number Of Residues | 192 |
| Number Of SNVs | 3 |
| Number Of Permutations | 336 |
| Optimal Distance Threshold | 38.0 |
| K Statistic | 0.667 |
| p-value | 0.396 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 57 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | -0.415 |
| p-value | 0.332 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
