General Structure Information
| PDB ID | 3eij |
| HGNC Gene Label(s) | PDCD4 |
| Structure Name | crystal structure of pdcd4 |
| Resolution | 2.8Å |
| Reference | AUTH P.G.LOH,H.-S.YANG,M.A.WALSH,Q.WANG,X.WANG,Z.CHENG,D.LIU,AUTH 2 H.SONGTITL STRUCTURAL BASIS FOR TRANSLATIONAL INHIBITION BY THE TUMOURTITL 2 SUPPRESSOR PDCD4REF EMBO J. V. 28 274 2009REFN ISSN 0261-4189PMID 19153607DOI 10.1038/EMBOJ.2008.278 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 274 |
| Number Of SNVs | 73 |
| Number Of Permutations | 18878 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.025 |
| p-value | 0.114 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 10:112645039 | L>W | A:157 | (-60.40, 99.49, -14.50) | |
| 10:112645041 | rs200942827 | P>S | A:158 | (-56.94, 97.77, -16.59) |
| 10:112645048 | D>G | A:160 | (-60.41, 94.56, -12.33) | |
| 10:112645063 | E>G | A:165 | (-57.02, 87.65, -18.23) | |
| 10:112645099 | E>G | A:177 | (-56.79, 68.93, -20.98) | |
| 10:112645107 | D>H | A:180 | (-66.33, 68.65, -16.64) | |
| 10:112645117 | E>V | A:183 | (-65.09, 71.27, -12.93) | |
| 10:112645123 | rs200393046 | A>V | A:185 | (-69.92, 75.86, -13.63) |
| 10:112647433 | rs41292600 | R>K | A:189 | (-72.31, 78.39, -9.44) |
| 10:112647444 | L>F | A:193 | (-68.56, 86.56, -12.23) | |
| 10:112647460 | S>N | A:198 | (-69.32, 88.82, -20.88) | |
| 10:112647465 | rs376917609 | V>I | A:200 | (-66.21, 83.88, -19.90) |
| 10:112647468 | P>T | A:201 | (-67.36, 83.97, -23.52) | |
| 10:112647474 | L>V | A:203 | (-60.99, 84.45, -22.21) | |
| 10:112647490 | A>G | A:208 | (-59.27, 78.61, -28.59) | |
| 10:112647496 | E>G | A:210 | (-54.17, 81.40, -29.04) | |
| 10:112647499 | G>E | A:211 | (-55.22, 76.44, -30.18) | |
| 10:112647508 | S>T | A:214 | (-60.12, 70.59, -30.24) | |
| 10:112647510 | H>Y | A:215 | (-58.96, 73.39, -27.63) | |
| 10:112647523 | T>I | A:219 | (-65.43, 76.62, -26.41) | |
| 10:112647531 | L>F | A:222 | (-68.31, 75.83, -22.15) | |
| 10:112647537 | S>A | A:224 | (-74.32, 75.64, -24.54) | |
| 10:112647541 | D>G | A:225 | (-73.43, 73.67, -21.30) | |
| 10:112647558 | M>L | A:231 | (-74.09, 82.98, -19.04) | |
| 10:112647565 | rs144940985 | T>I | A:233 | (-78.81, 85.17, -23.72) |
| 10:112647576 | E>K | A:237 | (-75.77, 89.54, -27.62) | |
| 10:112647586 | F>C | A:240 | (-70.38, 86.24, -29.91) | |
| 10:112647600 | K>E | A:245 | (-65.90, 95.67, -31.36) | |
| 10:112647610 | P>L | A:248 | (-58.94, 93.13, -35.82) | |
| 10:112647613 | E>A | A:249 | (-56.69, 92.45, -31.11) | |
| 10:112647637 | A>G | A:257 | (-60.31, 84.59, -36.80) | |
| 10:112649293 | L>F | A:260 | (-62.44, 80.25, -36.56) | |
| 10:112649312 | rs148027160 | R>G | A:267 | (-72.11, 75.15, -32.25) |
| 10:112649324 | D>N | A:271 | (-76.49, 75.55, -29.59) | |
| 10:112649340 | N>T | A:276 | (-81.37, 83.10, -36.74) | |
| 10:112649346 | Y>F | A:278 | (-75.99, 88.67, -33.64) | |
| 10:112649361 | rs544209088 | K>R | A:283 | (-75.67, 97.89, -38.87) |
| 10:112649376 | C>F | A:288 | (-64.57, 95.88, -40.62) | |
| 10:112649378 | rs532996701 | V>M | A:289 | (-63.38, 93.68, -43.81) |
| 10:112649381 | rs372001367 | Q>E | A:290 | (-61.39, 91.34, -40.25) |
| 10:112650325 | D>G | A:296 | (-70.35, 86.56, -44.59) | |
| 10:112650333 | rs147480610 | T>P | A:299 | (-74.75, 83.21, -43.20) |
| 10:112650336 | rs367566735 | V>M | A:300 | (-72.67, 80.18, -45.53) |
| 10:112650337 | V>A | A:300 | (-72.67, 80.18, -45.53) | |
| 10:112650354 | rs371329972 | K>E | A:306 | (-81.25, 73.84, -45.23) |
| 10:112650412 | N>S | A:325 | (-70.73, 59.30, -42.67) | |
| 10:112650413 | N>K | A:325 | (-70.73, 59.30, -42.67) | |
| 10:112653855 | M>V | A:333 | (-70.68, 71.04, -44.85) | |
| 10:112653857 | M>I | A:333 | (-70.68, 71.04, -44.85) | |
| 10:112653877 | L>P | A:340 | (-72.26, 79.00, -52.24) | |
| 10:112653879 | rs140003204 | S>P | A:341 | (-67.68, 80.83, -52.78) |
| 10:112653898 | A>G | A:347 | (-61.47, 74.24, -49.48) | |
| 10:112653903 | rs376545464 | H>Y | A:349 | (-57.49, 75.56, -44.55) |
| 10:112653927 | P>A | A:357 | (-55.00, 61.75, -45.60) | |
| 10:112653948 | V>L | A:364 | (-63.33, 62.71, -55.30) | |
| 10:112653952 | Y>F | A:365 | (-68.50, 59.37, -54.36) | |
| 10:112654179 | M>L | A:370 | (-72.31, 67.50, -56.09) | |
| 10:112654183 | rs530829510 | V>G | A:371 | (-71.03, 67.14, -61.22) |
| 10:112654194 | rs144787375 | T>A | A:375 | (-78.73, 71.61, -63.23) |
| 10:112654195 | T>S | A:375 | (-78.73, 71.61, -63.23) | |
| 10:112654203 | S>G | A:378 | (-71.81, 75.67, -63.09) | |
| 10:112654235 | K>N | A:388 | (-57.49, 71.23, -62.20) | |
| 10:112654249 | S>F | A:393 | (-51.42, 71.10, -54.23) | |
| 10:112654254 | T>A | A:395 | (-53.96, 67.94, -51.50) | |
| 10:112654268 | rs146453067 | D>E | A:399 | (-54.79, 56.09, -53.99) |
| 10:112654273 | rs201057391 | M>K | A:401 | (-58.02, 61.29, -57.62) |
| 10:112654276 | K>R | A:402 | (-57.06, 55.44, -58.52) | |
| 10:112655725 | N>S | A:410 | (-68.66, 50.45, -59.25) | |
| 10:112655734 | rs143151331 | P>L | A:413 | (-74.52, 51.63, -63.51) |
| 10:112655740 | rs368052826 | I>T | A:415 | (-76.12, 56.91, -60.66) |
| 10:112655748 | D>H | A:418 | (-82.05, 57.38, -60.52) | |
| 10:112655749 | D>V | A:418 | (-82.05, 57.38, -60.52) | |
| 10:112655764 | Y>F | A:423 | (-72.89, 56.25, -68.20) | |
| 10:112655767 | rs201111696 | S>C | A:424 | (-72.82, 61.98, -70.57) |
| 10:112655769 | V>L | A:425 | (-71.89, 64.07, -67.39) | |
| 10:112655778 | rs146655374 | R>W | A:428 | (-68.98, 66.04, -70.45) |
| 10:112655779 | COSM2052893 | R>Q | A:428 | (-68.98, 66.04, -70.45) |
| 10:112655797 | F>S | A:434 | (-56.57, 62.40, -69.99) | |
| 10:112655814 | rs140405638 | S>P | A:440 | (-54.18, 58.18, -65.77) |